公开(公告)号：US20240050523A1

公开(公告)日：2024-02-15

申请号：US18447152

申请日：2023-08-09

Applicant: SHIFTBIO INC. ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Gi-Hoon NAM ,  Gi Beom KIM ,  Jae Hyun KIM ,  Yeji LEE ,  Jiyoung GOO ,  Seongeun CHO ,  Cherlhyun JEONG ,  In-San KIM

IPC: A61K38/17 ,  A61K9/127 ,  A61K47/65 ,  A61P1/16 ,  A61P29/00 ,  A61K47/69 ,  A61K47/64

CPC classification number: A61K38/1709 ,  A61K9/127 ,  A61K38/177 ,  A61K47/65 ,  A61P1/16 ,  A61P29/00 ,  A61K47/6911 ,  A61K47/64

Abstract: The present invention generally relates to an extracellular vesicle (EV) comprising a subunit of a heterodimeric transcription factor, an EV polypeptide, and a monomeric cis-cleaving intein and a method of using the EV.

公开(公告)号：US20240024418A1

公开(公告)日：2024-01-25

申请号：US18357160

申请日：2023-07-24

Applicant: SHIFTBIO INC.

Inventor： Gi-Hoon NAM ,  Gi Beom KIM ,  Seohyun KIM ,  Yoon Kyoung KIM ,  Jae Hyun KIM ,  Seonghyun KIM

IPC: A61K38/17 ,  C12N5/0775 ,  C12N15/86 ,  A61K47/69 ,  A61P29/00 ,  A61P1/16

CPC classification number: A61K38/1774 ,  C12N5/0663 ,  C12N15/86 ,  A61K47/6901 ,  A61P29/00 ,  A61P1/16 ,  C12N2510/02 ,  C12N2740/15043

Abstract: The present invention generally relates to a stem cell-derived extracellular vesicle (EV) comprising a signal regulatory protein (SIRP) and a method for preventing or treating cancer and/or inflammatory disease, condition, or symptom by using the stem cell-derived EV.