LIQUID CHROMATOGRAPH MASS SPECTROMETER
    2.
    发明申请
    LIQUID CHROMATOGRAPH MASS SPECTROMETER 审中-公开
    液相色谱质谱仪

    公开(公告)号:US20160069848A1

    公开(公告)日:2016-03-10

    申请号:US14479874

    申请日:2014-09-08

    Abstract: In a liquid chromatograph mass spectrometer (LC/MS) for performing mass spectrometry of fractionated samples prepared with a multi-dimensional LC or similar LC with high separatory capability, fractionated sample useful information which shows the degree of usefulness of various substances with respect to retention time is prepared from prior information which includes, for example, elution characteristics in the LC depending on the kind of column or other factors or the degree of ease of ionization in the MS. During a measurement, the preparative separation of an eluate and the preparation of fractionated samples are not performed within a period of time which has been judged to be useless based on the fractionated sample useful information. By selecting fractionated samples at each dimension of the multi-dimensional LC, the number of fractionated samples to be eventually subjected to mass spectrometry can be significantly reduced.

    Abstract translation: 在用多维LC或具有高分离能力的LC制备的分级样品进行质谱分析的液相色谱质谱仪(LC / MS)中,分级样品有用信息显示各种物质在保留时的有用程度 时间由包括例如LC中的洗脱特性或其它因素的种类或MS中的电离容易程度的先验信息制备。 在测量过程中,洗脱液的制备分离和分级样品的制备不能在基于分级样品有用信息被判断为无用的时间段内进行。 通过在多维LC的每个维度处选择分级样品,可以显着减少最终进行质谱分析的样品数量。

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