公开(公告)号：US20150344502A1

公开(公告)日：2015-12-03

申请号：US14655893

申请日：2013-12-26

申请人： SHIONOGI & CO., LTD.

发明人： Kenji YAMAWAKI ,  Hiroki KUSANO

IPC分类号： C07D519/06 ,  C07D501/46

CPC分类号： C07D519/06 ,  A61K9/0019 ,  C07D501/46 ,  Y02A50/473

摘要： A compound of the formula: wherein, W is —CH2− etc.; U is —S− etc.; R1 is substituted or unsubstituted carbocyclyl etc.; R2A and R2B is a) or b) described in the specification; R3 is a hydrogen atom etc.; R11 is carboxylate anion (—COO−) etc.; L is substituted or unsubstituted lower alkylene etc., E is a substituted or unsubstituted divalent group containing quaternary ammonium ion; G is a single bond etc.; D is —C(═O)—C(═O)—NR6— etc.; R10 1) to 3) described in specification; or an amino-protected compound when the amino group is present on the ring in the 7-side chain, or a pharmaceutically acceptable salt thereof.

摘要翻译： 下式的化合物：其中，W是-CH 2 - 等; U是-S-等; R1是取代或未取代的碳环基等; R2A和R2B是说明书中描述的a）或b） R3是氢原子等。 R11是羧酸根阴离子（-COO-）等; L是取代或未取代的低级亚烷基等，E是取代或未取代的含二价基团的季铵离子; G是单键等; D是-C（= O）-C（= O）-NR 6 - 等; R10 1）〜3） 或当氨基存在于7-侧链的环上时的氨基保护的化合物或其药学上可接受的盐。

公开(公告)号：US20150299223A1

公开(公告)日：2015-10-22

申请号：US14439219

申请日：2013-10-29

申请人： GLAXO GROUP LIMITED ,  SHIONOGI & CO., LTD.

发明人： Toshiaki AOKI ,  Hiroki KUSANO ,  Xiangmin LIAO ,  Neil David PEARSON ,  Israil PENDRAK ,  Jun SATO ,  Reema THALGI ,  Kenji YAMAWAKI ,  Katsuki YOKOO

IPC分类号： C07D501/48

摘要： The present invention relates to 2-substituted cephem compounds of Formula (I) having a quaternary ammonium group on the 3-side chain, preferably together with a cathechol group, or pharmaceutically acceptable salts thereof, which exhibit potent antimicrobial spectrum against a variety of bacteria including Gram negative bacteria and/or Gram positive bacteria, corresponding pharmaceutical compositions, methods of making, treatment methods for bacterial infections or uses thereof.

摘要翻译： 本发明涉及在3-侧链上具有季铵基团的式（I）的2-取代头孢烯化合物，优选与导管胆固醇基团或其药学上可接受的盐，其表现出针对各种细菌的有效的抗菌谱 包括革兰氏阴性细菌和/或革兰氏阳性细菌，相应的药物组合物，制备方法，细菌感染的治疗方法或其用途。

公开(公告)号：US20180186814A1

公开(公告)日：2018-07-05

申请号：US15740103

申请日：2016-06-30

申请人： Shionogi & Co., Ltd.

发明人： Kenji YAMAWAKI ,  Hiroki KUSANO

IPC分类号： C07D501/14 ,  A61P31/04

CPC分类号： C07D501/14 ,  A61K31/546 ,  A61P31/04

摘要： The present invention provides a compound exhibiting a strong antimicrobial spectrum against various bacteria, including gram-negative bacteria, or a pharmaceutical composition having an antimicrobial activity carbapenem-resistant bacteria. Provided is a compound represented by formula (I), an ester thereof or a pharmaceutically acceptable salt thereof, or a hydrate thereof. (I) (in the formula, —W— is —S(═O)— or S(═O)2—, -T- is CR4AR4B— or —CR5A—R5B—CR6A—R6B—, each of R2A and R2B is independently a hydrogen atom, etc., or R2A and R2B together form a substituted or unsubstituted methylidene, etc., R3 is a hydrogran atom, etc., R11 is a carboxyl, etc., and each of R7A and R7B is independently a hydrogen atom, etc.)

公开(公告)号：US20140187535A1

公开(公告)日：2014-07-03

申请号：US14138965

申请日：2013-12-23

申请人： Shionogi & Co., Ltd. ,  Purdue Pharma L.P.

发明人： Nobuyuki TANAKA ,  Kenji YAMAWAKI ,  Jiangchao YAO ,  Jianming YU ,  Xiaoming ZHOU

IPC分类号： C07D471/08 ,  C07D401/04

CPC分类号： C07D471/08 ,  C07D401/04

摘要： The disclosure relates to Substituted Benzimidazole-Type Piperidine Compounds of Formula (I): and pharmaceutically acceptable salts or solvates thereof, e.g., a pharmaceutically acceptable salt or solvate, wherein R1, R2, R3, Qa, W, U, A, B, Z, a, and the dashed lines are as defined herein, compositions comprising an effective amount of a Substituted Benzimidazole-Type Piperidine Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted Benzimidazole-Type Piperidine Compound.

摘要翻译： 本公开涉及式（I）的取代的苯并咪唑型哌啶化合物及其药学上可接受的盐或溶剂化物，例如药学上可接受的盐或溶剂化物，其中R1，R2，R3，Qa，W，U，A， Z，a和虚线如本文所定义，包含有效量的取代的苯并咪唑型哌啶化合物的组合物，以及治疗或预防诸如疼痛的病症的方法包括向有需要的动物施用有效的 取代的苯并咪唑型哌啶化合物的量。