公开(公告)号：US11655295B2

公开(公告)日：2023-05-23

申请号：US16963067

申请日：2019-01-03

申请人： SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

发明人： Tongtong Xue ,  Qiang Li ,  Liang Xiao ,  Yuncheng Zheng ,  Dengnian Liu ,  Si Chen ,  Yan Hu ,  Lichun Wang ,  Jingyi Wang

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00

CPC分类号： C07K16/2803 ,  A61K39/39558 ,  A61P35/00

摘要： The present invention relates to the field of treatment of diseases and immunology. Specifically, the present invention relates to an anti-LAG-3 antibody or an antigen-binding fragment thereof, nucleic acid molecules for encoding said antibody and fragment, and method for preparing said antibody and fragment. The anti-LAG-3 antibody or the antigen-binding fragment thereof according to the present invention has high specificity and high affinity to LAG-3, can effectively block the binding of LAG-3 to MHC II and/or FGL1, and can inhibit and/or block intracellular signaling mediated by LAG-3 binding to MHC II and/or FGL1. Therefore, the present invention further relates to a pharmaceutical composition comprising the antibody or the antigen-binding fragment thereof, and use of the pharmaceutical composition in the preparation of drugs. The drugs are used for improving the activity of immune cells and enhancing the immune response, or are used for preventing and/or treating tumors, infections or autoimmune diseases.

公开(公告)号：US20210238282A1

公开(公告)日：2021-08-05

申请号：US17050161

申请日：2019-04-22

申请人： AMPSOURCE BIOPHARMA SHANGHAI INC. ,  SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

发明人： Qiang Li ,  Tongtong Xue ,  Yuncheng Zheng ,  Liang Xiao ,  Dengnian Liu ,  Jianyu Sun ,  Jiangjiang Hu ,  Xinlu Ma ,  Kangyong Zhu ,  Yuanli Li

IPC分类号： C07K16/28 ,  A61K45/06 ,  A61P35/00 ,  C12N5/12 ,  A61K39/00

摘要： Provided by the present invention are an antibody against human TIM-3 or an antigen-binding fragment thereof, and further provided are a nucleic acid molecule encoding the antibody, an expression vector for expressing the antibody and a host cell, and a method for producing the antibody. Further provided by the present invention are a pharmaceutical composition comprising the antibody or an antigen-binding fragment of the antibody, and an application of the pharmaceutical composition in the preparation of a medicine, the medicine is used for preventing and/or treating various diseases (including tumors, infectious diseases and autoimmune diseases).