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公开(公告)号：US20240269312A1
公开(公告)日：2024-08-15
申请号：US18558201
申请日：2022-05-23
发明人： Haijun TIAN , Qiang TIAN , Xiaoxi YUAN , Ying-Hua CHANG , Deliang LI , Jiangjiang HU , Yitao ZHANG , Xiaobei WANG , Yong ZHENG , Jian YE , Bo WANG , Yu MIAO , Bingqiang KANG , Fen LI , Zujian TANG , Hanwen DENG , Hongmei SONG , Junyou GE , Jingyi WANG
CPC分类号： A61K47/6849 , A61K47/68031 , A61K47/68033 , A61K47/68035 , A61K47/68037 , A61K47/6807 , A61K47/6809 , A61K47/6831 , A61K47/6889 , A61P35/00
摘要： Provided in the present application are an antibody-drug conjugate, and a preparation method therefor and the use thereof. The antibody drug conjugate has a structure as represented by the formula Ab-[M-L-E-D]x, and the drug is selected from an anti-tubulin agent, a DNA intercalator, a DNA topoisomerase inhibitor and a RNA polymerase inhibitor. The prepared antibody-drug conjugate has a better drug-to-antibody ratio, and has a good targeted killing effect on colon cancer and non-small cell lung cancer (for example, lung adenocarcinoma).
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公开(公告)号：US20240252665A1
公开(公告)日：2024-08-01
申请号：US18559039
申请日：2022-05-23
发明人： Qiang TIAN , Xiaobei WANG , Deliang LI , Yitao ZHANG , Jian YE , Ruibin HU , Hongmei SONG , Junyou GE , Jingyi WANG
CPC分类号： A61K47/68037 , A61K47/545 , A61K47/65 , A61K47/6849 , A61P35/00
摘要： The present invention relates to a chemical coupling linker and use thereof, and a bioactive conjugate prepared by the chemical coupling linker. The present invention also relates to use of the bioactive conjugate in the preparation of a drug for the prevention or treatment of tumor diseases.
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公开(公告)号：US11655295B2
公开(公告)日：2023-05-23
申请号：US16963067
申请日：2019-01-03
发明人： Tongtong Xue , Qiang Li , Liang Xiao , Yuncheng Zheng , Dengnian Liu , Si Chen , Yan Hu , Lichun Wang , Jingyi Wang
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
CPC分类号： C07K16/2803 , A61K39/39558 , A61P35/00
摘要： The present invention relates to the field of treatment of diseases and immunology. Specifically, the present invention relates to an anti-LAG-3 antibody or an antigen-binding fragment thereof, nucleic acid molecules for encoding said antibody and fragment, and method for preparing said antibody and fragment. The anti-LAG-3 antibody or the antigen-binding fragment thereof according to the present invention has high specificity and high affinity to LAG-3, can effectively block the binding of LAG-3 to MHC II and/or FGL1, and can inhibit and/or block intracellular signaling mediated by LAG-3 binding to MHC II and/or FGL1. Therefore, the present invention further relates to a pharmaceutical composition comprising the antibody or the antigen-binding fragment thereof, and use of the pharmaceutical composition in the preparation of drugs. The drugs are used for improving the activity of immune cells and enhancing the immune response, or are used for preventing and/or treating tumors, infections or autoimmune diseases.
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公开(公告)号：US11434235B2
公开(公告)日：2022-09-06
申请号：US16981430
申请日：2019-05-06
发明人： Tianming Wang , Chengxi Yang , Jiaqiang Cai , Wei Liu , Baolei Zhang , Qiang Tian , Shuai Song , Hao Hu , Weibiao Han , Youqiang Li , Xing Chen , Lichun Wang , Jingyi Wang
IPC分类号： C07D417/14 , A61K45/06
摘要： Disclosed are a solid form of (E)-3-((R)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)acrylic acid, a preparation method therefor, a pharmaceutical composition comprising same, and the use thereof in the preparation of drugs for preventing or treating viral diseases.
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公开(公告)号：US20220056043A1
公开(公告)日：2022-02-24
申请号：US17416064
申请日：2020-02-10
发明人： GUIYING LI , Zejin YOU , Yun HE , Qiang TIAN , Hongmei SONG , Tongtong XUE , Jingyi WANG
IPC分类号： C07D495/04 , A61P35/00
摘要： The present invention relates to a nitrogen-containing fused ring compound, a preparation method and use thereof. Specifically, the present invention relates to a compound having the structure of Formula (X), a stereoisomer, tautomer or mixture thereof, a pharmaceutically acceptable salt, co-crystal, polymorph or solvate thereof, or a stable isotope derivative, metabolite or prodrug thereof. The compound of the invention may have the structure of Formula (I) or Formula (II). These compounds are useful for the treatment of an abnormal cell proliferation disease (e.g., cancer).
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公开(公告)号：US20220017483A1
公开(公告)日：2022-01-20
申请号：US17289476
申请日：2019-12-19
发明人： Jinming LIU , Ting HE , Jiaqiang CAI , Zhenewn DONG , Qiang TIAN , Hongmei SONG , Tongtong XUE , Lichun WANG , Jingyi WANG
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14
摘要： Disclosed by the present invention are an aminopyridine compound, a preparation method therefor and a use thereof, which are specifically an aminopyridine compound represented by formula (I), a pharmaceutical composition containing same, a preparation method therefor and a use thereof in preventing or treating diseases related to adenosine A2a receptors.
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公开(公告)号：US20210024514A1
公开(公告)日：2021-01-28
申请号：US16981430
申请日：2019-05-06
发明人： TIANMING WANG , CHENGXI YANG , JIAQIANG CAI , WEI LIU , BAOLEI ZHANG , QIANG TIAN , SHUAI SONG , HAO HU , WEIBIAO HAN , YOUQIANG LI , XING CHEN , LICHUN WANG , JINGYI WANG
IPC分类号： C07D417/14
摘要： Disclosed are a solid form of (E)-3-((R)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)acrylic acid, a preparation method therefor, a pharmaceutical composition comprising same, and the use thereof in the preparation of drugs for preventing or treating viral diseases.
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公开(公告)号：US20200239429A1
公开(公告)日：2020-07-30
申请号：US16652274
申请日：2018-11-15
发明人： Jiawang ZHU , Zhiquan SONG , Dong LONG , Lichun WANG , Jingyi WANG
IPC分类号： C07D401/04 , C07D333/56 , C07D215/14 , C07D215/227 , C07D215/38 , C07D413/04 , C07D215/36 , A61P1/16
摘要： The invention relates to an aromatic compound, pharmaceutical composition comprising the same, and a method for preparing the compound and an intermediate thereof. The invention also relates to use of the compound for the manufacture of a medicament for the prevention or treatment of a PPAR-related disease.
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公开(公告)号：US20190225603A1
公开(公告)日：2019-07-25
申请号：US16334237
申请日：2017-11-09
发明人： Shuai SONG , Jiaqiang CAI , Qiang TIAN , Hong ZENG , Hongmei SONG , Hanwen DENG , Zujian TANG , XIAOFAN DUAN , Rongrong LONG , Yao LIU , Lichun WANG , Jingyi WANG
IPC分类号： C07D417/14 , A61P31/16 , A61P31/22
摘要： The present invention relates to a dihydropyrimidine compound having an antiviral activity, a pharmaceutical composition comprising same, a preparation method therefor and the uses thereof in the prevention or treatment of viral diseases including, but not limited to, Hepatitis A, Hepatitis B, Hepatitis C, influenza, herpes and acquired immunodeficiency syndrome (AIDS).
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公开(公告)号：US10159662B2
公开(公告)日：2018-12-25
申请号：US15767508
申请日：2016-12-08
发明人： Yinong Xie , Zejin You , Zhiwen Deng , Jun Zhu , Ao Wang , Yan Feng , Dong Long , Hong Zeng , Hongmei Song , Qijun Ye , Wei Qi , Donghai Su , Lichun Wang , Jingyi Wang
IPC分类号： A61K31/437 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61K39/00 , A61K31/343 , A61K38/17 , A61K31/519
摘要： The present invention relates to an azetidine derivative for use as a Janus kinase (JAK) inhibitor, a drug composition comprising same, a preparation method therefor, and a use thereof in the treatment of JAK-related diseases comprising, for example, inflammatory diseases, autoimmune diseases, and cancers.
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