公开(公告)号：US11266710B2

公开(公告)日：2022-03-08

申请号：US16641978

申请日：2018-08-31

申请人： SINGAPORE HEALTH SERVICES PTE LTD ,  NATIONAL UNIVERSITY OF SINGAPORE

发明人： Michael Belkin ,  Veluchamy Amutha Barathi ,  Rajamani Lakshminarayanan ,  R. Manjunatha Kini ,  Ge Ruowen ,  Tien Yin Wong ,  Gemmy Chui Ming Cheung

IPC分类号： A61K38/08 ,  A61K38/16 ,  A61K9/00 ,  A61P27/02 ,  C07K7/06 ,  C07K7/00 ,  C07K14/00

摘要： This disclosure provides methods of a method of treating a retinal angiogenic in a subject comprising administering an effective amount of an Angio-3 peptide.

公开(公告)号：US10906946B2

公开(公告)日：2021-02-02

申请号：US15737266

申请日：2016-06-17

申请人： National University of Singapore ,  Institute of Zoology, Slovak Academy of Sciences

发明人： Janaki Krishnamoorthy Iyer ,  Cho Yeow Koh ,  R. Manjunatha Kini ,  Maria Kazimirova ,  Ladislav Roller

IPC分类号： C07K14/435 ,  C07K14/81 ,  A61P7/02 ,  A61K38/00

摘要： The present invention provides isolated peptides, variants and fragments thereof that are capable of binding with a high level of specificity to thrombin and inhibiting its activity. There is also provided uses of such peptides in methods of diagnosis and treatment, coating of medical devices and nucleic acids encoding the same.