公开(公告)号：US20150011628A1

公开(公告)日：2015-01-08

申请号：US14376074

申请日：2013-03-06

申请人： SINOCHEM CORPORATION ,  SHENYANG RESEARCH INSTITUTE OF CHEMICAL INDUSTRY CO., LTD.

发明人： Changling Liu ,  Baoshan Chai ,  Huichao Li ,  Aiying Guan

IPC分类号： C07C255/58 ,  C07C205/37 ,  C07C205/06

CPC分类号： C07C255/58 ,  A61K31/136 ,  A61K31/277 ,  C07C205/06 ,  C07C205/37 ,  C07C211/56 ,  C07C217/92 ,  C07C229/58 ,  C07C233/65 ,  C07C255/57 ,  C07C255/59 ,  C07C323/36 ,  C07D213/643

摘要： The invention relates to substituted diphenylamine compounds using as antitumor agents. The structure of the compounds is represented as the general formula (I): The groups are as defined as specification.The compound represented by formula (I) showed potent antitumor activity, especially to cure or alleviate the cancer causing by cancer cells of human tissue or organ. The preferred cancers are: colon cancer, liver cancer, lymph cancer, lung cancer, esophageal cancer, breast cancer, central nervous system cancer, melanoma, ovarian cancer, cervical cancer, renal cancer, leukemia, prostatic cancer, pancreatic cancer, bladder cancer, rectal cancer, osteosarcoma, nasopharynx cancer or stomach cancer.

摘要翻译： 本发明涉及用作抗肿瘤剂的取代二苯胺化合物。 化合物的结构用通式（I）表示：这些基团如规定所定义。 由式（I）表示的化合物显示出有效的抗肿瘤活性，特别是用于治疗或减轻由人体组织或器官的癌细胞引起的癌症。 优选的癌症是：结肠癌，肝癌，淋巴癌，肺癌，食管癌，乳腺癌，中枢神经系统癌，黑素瘤，卵巢癌，子宫颈癌，肾癌，白血病，前列腺癌，胰腺癌，膀胱癌， 直肠癌，骨肉瘤，鼻咽癌或胃癌。

公开(公告)号：US09376376B2

公开(公告)日：2016-06-28

申请号：US14376074

申请日：2013-03-06

申请人： SINOCHEM CORPORATION ,  SHENYANG RESEARCH INSTITUTE OF CHEMICAL INDUSTRY CO., LTD.

发明人： Changling Liu ,  Baoshan Chai ,  Huichao Li ,  Aiying Guan

IPC分类号： C07C255/58 ,  A61K31/136 ,  C07C211/56 ,  C07C205/06 ,  C07C205/37 ,  A61K31/277 ,  C07C255/57 ,  C07C255/59 ,  C07C217/92 ,  C07C323/36 ,  C07C229/58 ,  C07C233/65 ,  C07D213/643

CPC分类号： C07C255/58 ,  A61K31/136 ,  A61K31/277 ,  C07C205/06 ,  C07C205/37 ,  C07C211/56 ,  C07C217/92 ,  C07C229/58 ,  C07C233/65 ,  C07C255/57 ,  C07C255/59 ,  C07C323/36 ,  C07D213/643

摘要： The invention relates to substituted diphenylamine compounds using as antitumor agents. The structure of the compounds is represented as the general formula (I): The groups are as defined as specification.The compound represented by formula (I) showed potent antitumor activity, especially to cure or alleviate the cancer causing by cancer cells of human tissue or organ. The preferred cancers are: colon cancer, liver cancer, lymph cancer, lung cancer, esophageal cancer, breast cancer, central nervous system cancer, melanoma, ovarian cancer, cervical cancer, renal cancer, leukemia, prostatic cancer, pancreatic cancer, bladder cancer, rectal cancer, osteosarcoma, nasopharynx cancer or stomach cancer.

摘要翻译： 本发明涉及用作抗肿瘤剂的取代二苯胺化合物。 化合物的结构表示为通式（I）：这些基团如规定所定义。 由式（I）表示的化合物显示出有效的抗肿瘤活性，特别是用于治疗或减轻由人体组织或器官的癌细胞引起的癌症。 优选的癌症是：结肠癌，肝癌，淋巴癌，肺癌，食管癌，乳腺癌，中枢神经系统癌，黑素瘤，卵巢癌，子宫颈癌，肾癌，白血病，前列腺癌，胰腺癌，膀胱癌， 直肠癌，骨肉瘤，鼻咽癌或胃癌。