公开(公告)号：US12129221B2

公开(公告)日：2024-10-29

申请号：US17325193

申请日：2021-05-19

申请人： SIRONAX LTD

发明人： Zhiyuan Zhang ,  Yaning Su ,  Yi Yang ,  Guozheng Wang ,  Wendong Liu ,  Yongfen Ma ,  Yan Ren

IPC分类号： C07C233/13 ,  A61P25/28 ,  A61P31/12 ,  A61P35/00

CPC分类号： C07C233/13 ,  A61P25/28 ,  A61P31/12 ,  A61P35/00

摘要： The disclosed compounds inhibit cellular necrosis, and include corresponding sulfonamides, prodrugs and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

公开(公告)号：US20210284598A1

公开(公告)日：2021-09-16

申请号：US17325193

申请日：2021-05-19

申请人： SIRONAX LTD

发明人： Zhiyuan Zhang ,  Yaning Su ,  Yi Yang ,  Guozheng Wang ,  Wendong Liu ,  Yongfen Ma ,  Yan Ren

IPC分类号： C07C233/13 ,  A61P25/28 ,  A61K9/00

摘要： The invention provides amides that inhibit cellular necrosis including corresponding sulfonamides, prodrugs and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.