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公开(公告)号：US20220362235A1
公开(公告)日：2022-11-17
申请号：US17866877
申请日：2022-07-18
申请人： SLAYBACK PHARMA LLC
发明人： Sushant Omprakash DUBE , Suprit Dilip SAOJI , Pankaj Kisan CHATKI , Sumitra Ashokkumar PILLAI , Girish G. KORE
摘要： Pharmaceutical compositions are provided, which comprise cabozantinib or pharmaceutically acceptable salts thereof, and at least one pharmaceutically acceptable excipient, wherein the inventive compositions exhibit enhanced bioavailability compared to the currently marketed or commercially available formulations. The present invention also provides manufacturing processes thereof and use of the said inventive compositions for the prevention, treatment or prophylaxis of disorders in human patients in need thereof. The present invention relates to oral pharmaceutical compositions of cabozantinib, methods for their administration, processes for their production, and use of these compositions for treatment of diseases treatable by cabozantinib.
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公开(公告)号：US20240131018A1
公开(公告)日：2024-04-25
申请号：US18523274
申请日：2023-11-29
申请人： SLAYBACK PHARMA LLC
发明人： Sushant Omprakash DUBE , Suprit Dilip SAOJI , Pankaj Kisan CHATKI , Sumitra Ashokkumar PILLAI , Girish G. KORE
摘要： Pharmaceutical compositions suitable for oral administration (such as a tablet or a capsule) are provided, which comprise a therapeutically effective amount of an amorphous solid dispersion of cabozantinib, e.g., for treating a proliferative disorder. Preferably, the amorphous solid dispersion consists of (a) cabozantinib or a pharmaceutically acceptable salt thereof (such as cabozantinib (S)-malate); (b) at least one pharmaceutically acceptable carrier selected from the group consisting of hydroxypropyl methyl cellulose acetate succinate (HPMC-AS), polyvinyl pyrrolidine and vinyl acetate (PVP/VA) copolymer, hydroxypropyl methylcellulose phthalate (HPMCP), and mixtures thereof; (c) a pore-forming agent; and (d) a plasticizer.
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公开(公告)号：US20220387418A1
公开(公告)日：2022-12-08
申请号：US17885105
申请日：2022-08-10
申请人： SLAYBACK PHARMA LLC
发明人： Sushant Omprakash DUBE , Suprit Dilip SAOJI , Pankaj Kisan CHATKI , Sumitra Ashokkumar PILLAI , Girish G. KORE
摘要： Pharmaceutical compositions are provided, which comprise cabozantinib or pharmaceutically acceptable salts thereof, and at least one pharmaceutically acceptable excipient, wherein the inventive compositions exhibit enhanced bioavailability compared to the currently marketed or commercially available formulations. The present invention also provides manufacturing processes thereof and use of the said inventive compositions for the prevention, treatment or prophylaxis of disorders in human patients in need thereof. The present invention relates to oral pharmaceutical compositions of cabozantinib, methods for their administration, processes for their production, and use of these compositions for treatment of diseases treatable by cabozantinib.
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公开(公告)号：US20220280500A1
公开(公告)日：2022-09-08
申请号：US17824518
申请日：2022-05-25
申请人： SLAYBACK PHARMA LLC
发明人： Sushant Omprakash DUBE , Suprit Dilip SAOJI , Pankaj Kisan CHATKI , Sumitra Ashokkumar PILLAI , Girish G. KORE
摘要： Pharmaceutical compositions are provided, which comprise cabozantinib or pharmaceutically acceptable salts thereof, and at least one pharmaceutically acceptable excipient, wherein the inventive compositions exhibit enhanced bioavailability compared to the currently marketed or commercially available formulations. The present invention also provides manufacturing processes thereof and use of the said inventive compositions for the prevention, treatment or prophylaxis of disorders in human patients in need thereof. The present invention relates to oral pharmaceutical compositions of cabozantinib, methods for their administration, processes for their production, and use of these compositions for treatment of diseases treatable by cabozantinib.
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公开(公告)号：US20230270736A1
公开(公告)日：2023-08-31
申请号：US18312857
申请日：2023-05-05
申请人： SLAYBACK PHARMA LLC
发明人： Sushant Omprakash DUBE , Suprit Dilip SAOJI , Pankaj Kisan CHATKI , Sumitra Ashokkumar PILLAI , Girish G. KORE
摘要： Pharmaceutical compositions are provided, which comprise cabozantinib or pharmaceutically acceptable salts thereof, and at least one pharmaceutically acceptable excipient, wherein the inventive compositions exhibit enhanced bioavailability compared to the currently marketed or commercially available formulations. The present invention also provides manufacturing processes thereof and use of the said inventive compositions for the prevention, treatment or prophylaxis of disorders in human patients in need thereof. The present invention relates to oral pharmaceutical compositions of cabozantinib, methods for their administration, processes for their production, and use of these compositions for treatment of diseases treatable by cabozantinib.
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公开(公告)号：US20230181561A1
公开(公告)日：2023-06-15
申请号：US18108423
申请日：2023-02-10
申请人： SLAYBACK PHARMA LLC
发明人： Sushant Omprakash DUBE , Suprit Dilip SAOJI , Pankaj Kisan CHATKI , Sumitra Ashokkumar PILLAI , Girish G. KORE
摘要： Pharmaceutical compositions are provided, which comprise cabozantinib or pharmaceutically acceptable salts thereof, and at least one pharmaceutically acceptable excipient, wherein the inventive compositions exhibit enhanced bioavailability compared to the currently marketed or commercially available formulations. The present invention also provides manufacturing processes thereof and use of the said inventive compositions for the prevention, treatment or prophylaxis of disorders in human patients in need thereof. The present invention relates to oral pharmaceutical compositions of cabozantinib, methods for their administration, processes for their production, and use of these compositions for treatment of diseases treatable by cabozantinib.
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公开(公告)号：US20220265633A1
公开(公告)日：2022-08-25
申请号：US17673583
申请日：2022-02-16
申请人： SLAYBACK PHARMA LLC
发明人： Sushant Omprakash DUBE , Suprit Dilip SAOJI , Pankaj Kisan CHATKI , Sumitra Ashokkumar PILLAI , Girish G. KORE
摘要： Pharmaceutical compositions are provided, which comprise cabozantinib or pharmaceutically acceptable salts thereof, and at least one pharmaceutically acceptable excipient, wherein the inventive compositions exhibit enhanced bioavailability compared to the currently marketed or commercially available formulations. The present invention also provides manufacturing processes thereof and use of the said inventive compositions for the prevention, treatment or prophylaxis of disorders in human patients in need thereof. The present invention relates to oral pharmaceutical compositions of cabozantinib, methods for their administration, processes for their production, and use of these compositions for treatment of diseases treatable by cabozantinib.
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