公开(公告)号：US20150111767A1

公开(公告)日：2015-04-23

申请号：US14383574

申请日：2013-03-07

Applicant: SMART Biotech Ltd.

Inventor： Tamar Jehuda-Cohen

IPC: G01N33/576

CPC classification number: G01N33/576

Abstract: The present invention relates to an improved method for detecting antibodies to a hepatitis virus in a tissue sample from individuals, which can reliably detect antibodies in recently infected individuals and which provides much lower false positive results in individuals that have cleared their hepatitis infections. More particularly, the present invention relates to an improved method and kit which utilizes an activator of (i) hepatitis virus-primed lymphocytes, (ii) memory cells specific for said hepatitis virus, (iii) hepatitis virus-specific antibody production, or (iv) a combination thereof in a tissue sample to stimulate the production of antibodies from newly primed B cells, if present.

Abstract translation: 本发明涉及一种用于检测来自个体的组织样品中的肝炎病毒抗体的改进方法，其可以可靠地检测最近感染的个体中的抗体，并且在清除了其肝炎感染的个体中提供了更低的假阳性结果。 更具体地，本发明涉及利用（i）肝炎病毒引发的淋巴细胞的激活剂，（ii）对所述肝炎病毒特异性的记忆细胞，（iii）肝炎病毒特异性抗体产生或（ iv）组合样品中的组合，以刺激来自新引发的B细胞（如果存在）的抗体的产生。