公开(公告)号：US11065322B2

公开(公告)日：2021-07-20

申请号：US16749556

申请日：2020-01-22

Applicant: SOCPRA—SCIENCES ET GENIE, s.e.c.

Inventor： Francois Malouin ,  Marianne Allard ,  Christian Lebeau Jacob ,  Brian Geoffrey Talbot ,  Daniel Scholl ,  Pierre Lacasse ,  Moussa S. Diarra ,  Celine Ster

IPC: A61K39/085 ,  C12Q1/689 ,  G01N33/569 ,  A61K39/00

Abstract: Agents, compositions, methods and kits useful for the treatment and diagnosis of Staphylococcal intramammary infection are disclosed. The agents, compositions, methods and kits are derived from genes expressed during Staphylococcal intramammary infection, and more particularly genes SACOL0442, based on the gene nomenclature from the Staphylococcus aureus COL (SACOL) genome.

公开(公告)号：US11129884B2

公开(公告)日：2021-09-28

申请号：US16749597

申请日：2020-01-22

Applicant: SOCPRA—SCIENCES ET GENIE, s.e.c.

Inventor： Francois Malouin ,  Marianne Allard ,  Christian Lebeau Jacob ,  Brian Geoffrey Talbot ,  Daniel Scholl ,  Pierre Lacasse ,  Moussa S. Diarra ,  Celine Ster

IPC: A61K39/085 ,  G01N33/569 ,  C12Q1/689 ,  A61K39/00

Abstract: Agents, compositions, methods and kits useful for the treatment and diagnosis of Staphylococcal intramammary infection are disclosed. The agents, compositions, methods and kits are derived from genes expressed during Staphylococcal intramammary infection, and more particularly genes SACOL0029, based on the gene nomenclature from the Staphylococcus aureus COL (SACOL) genome.

公开(公告)号：US09993491B2

公开(公告)日：2018-06-12

申请号：US14616164

申请日：2015-02-06

Applicant: SOCPRA—SCIENCES ET GENIE S.E.C.

Inventor： Jerome Mulhbacher ,  Daniel Lafontaine ,  Francois Malouin ,  Marianne Allard ,  Eric Marsault

IPC: A61K31/505 ,  A61K31/513 ,  A61K31/675 ,  A61K31/54 ,  A61K31/535 ,  A61K31/542 ,  A61K31/519 ,  A61K31/5383 ,  A61K31/4412 ,  C07D239/46 ,  C07D239/48 ,  C07D239/50 ,  C07D498/04 ,  C07D513/04

CPC classification number: A61K31/675 ,  A61K31/4412 ,  A61K31/505 ,  A61K31/513 ,  A61K31/519 ,  A61K31/535 ,  A61K31/5383 ,  A61K31/54 ,  A61K31/542 ,  C07D239/46 ,  C07D239/48 ,  C07D239/50 ,  C07D498/04 ,  C07D513/04 ,  Y10T436/141111 ,  Y10T436/143333

Abstract: The present invention includes novel compounds and pharmaceutically acceptable formulations of said compounds which exhibit antibiotic activity against microorganisms bearing a guanine riboswitch that controls the expression of the guaA gene, including organisms which are resistant to certain antibiotic families, and which are useful as antibacterial agents for treatment or prophylaxis of bacterial infections in animals or in humans, in particular but not limited to infections of the mammary gland, or their use as antiseptics, agents for sterilization or disinfection.