公开(公告)号：US20210393762A1

公开(公告)日：2021-12-23

申请号：US17410908

申请日：2021-08-24

Applicant: SOCPRA - SCIENCES ET GENIE, s.e.c.

Inventor： FRANCOIS MALOUIN ,  MARIANNE ALLARD ,  CHRISTIAN LEBEAU JACOB ,  BRIAN GEOFFREY TALBOT ,  DANIEL SCHOLL ,  PIERRE LACASSE ,  MOUSSA S. DIARRA ,  CELINE STER

IPC: A61K39/085 ,  G01N33/569 ,  C12Q1/689

Abstract: Agents, compositions, methods and kits useful for the treatment and diagnosis of Staphylococcal intramammary infection are disclosed. The agents, compositions, methods and kits are derived from genes expressed during Staphylococcal intramammary infection, and more particularly genes SACOL0029, based on the gene nomenclature from the Staphylococcus aureus COL (SACOL) genome.

公开(公告)号：US20200147197A1

公开(公告)日：2020-05-14

申请号：US16749597

申请日：2020-01-22

Applicant: SOCPRA - SCIENCES ET GENIE, s.e.c.

Inventor： FRANCOIS MALOUIN ,  MARIANNE ALLARD ,  CHRISTIAN LEBEAU JACOB ,  BRIAN GEOFFREY TALBOT ,  DANIEL SCHOLL ,  PIERRE LACASSE ,  MOUSSA S. DIARRA ,  CELINE STER

IPC: A61K39/085 ,  C12Q1/689 ,  G01N33/569

Abstract: Agents, compositions, methods and kits useful for the treatment and diagnosis of Staphylococcal intramammary infection are disclosed. The agents, compositions, methods and kits are derived from genes expressed during Staphylococcal intramammary infection, and more particularly genes SACOL0029, based on the gene nomenclature from the Staphylococcus aureus COL (SACOL) genome.

公开(公告)号：US20150150890A1

公开(公告)日：2015-06-04

申请号：US14616164

申请日：2015-02-06

Applicant: SOCPRA - SCIENCES ET GENIE S.E.C.

Inventor： JEROME MULHBACHER ,  DANIEL LAFONTAINE ,  FRANCOIS MALOUIN ,  MARIANNE ALLARD ,  ERIC MARSAULT

IPC: A61K31/675 ,  A61K31/54 ,  A61K31/535 ,  A61K31/542 ,  A61K31/505 ,  A61K31/519 ,  A61K31/5383 ,  A61K31/513 ,  A61K31/4412

CPC classification number: A61K31/675 ,  A61K31/4412 ,  A61K31/505 ,  A61K31/513 ,  A61K31/519 ,  A61K31/535 ,  A61K31/5383 ,  A61K31/54 ,  A61K31/542 ,  C07D239/46 ,  C07D239/48 ,  C07D239/50 ,  C07D498/04 ,  C07D513/04 ,  Y10T436/141111 ,  Y10T436/143333

Abstract: The present invention includes novel compounds and pharmaceutically acceptable formulations of said compounds which exhibit antibiotic activity against microorganisms bearing a guanine riboswitch that controls the expression of the guaA gene, including organisms which are resistant to certain antibiotic families, and which are useful as antibacterial agents for treatment or prophylaxis of bacterial infections in animals or in humans, in particular but not limited to infections of the mammary gland, or their use as antiseptics, agents for sterilization or disinfection.

Abstract translation: 本发明包括所述化合物的新化合物和药学上可接受的制剂，其对具有控制guaA基因表达的鸟嘌呤核糖开关的微生物具有抗生素活性，包括对某些抗生素家族具有抗性的生物体，并且其可用作抗细菌剂 治疗或预防动物或人类的细菌感染，特别是但不限于乳腺感染，或其作为防腐剂的用途，用于灭菌或消毒的试剂。