公开(公告)号：US20190240149A1

公开(公告)日：2019-08-08

申请号：US16386983

申请日：2019-04-17

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Marina Shevachman ,  Amira Ze' Evi ,  Eilon Asculai ,  Batella Binyaminovich ,  Nir Avram ,  Chaim Aschkenasy

IPC: A61K9/00 ,  A61K47/02 ,  A61K31/7056 ,  A61K31/565 ,  A61K31/4436 ,  A61K31/4174 ,  A61K31/4164 ,  A61K31/327 ,  A61K31/203 ,  A61K31/192 ,  A61K31/05 ,  A61K9/16 ,  A61K9/14 ,  A61K9/06 ,  A61K45/06

CPC classification number: A61K9/0034 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/143 ,  A61K9/1611 ,  A61K31/05 ,  A61K31/192 ,  A61K31/203 ,  A61K31/327 ,  A61K31/4164 ,  A61K31/4174 ,  A61K31/4436 ,  A61K31/565 ,  A61K31/7056 ,  A61K45/06 ,  A61K47/02

Abstract: Topical vaginal compositions are disclosed herein which include silica microspheres and an active ingredient in the amount of 0.001 to 15.0% w/w selected from estradiol, metronidazole, clindamycin, butoconazole, and combinations thereof. The topical compositions provide sustained release of the active ingredient so as to reduce skin irritation.

公开(公告)号：US11865208B2

公开(公告)日：2024-01-09

申请号：US17023625

申请日：2020-09-17

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Marina Shevachman ,  Amira Ze' Evi ,  Eilon Asculai ,  Batella Benyaminovich ,  Nir Avram ,  Chaim Aschkenasy

IPC: A61K9/00 ,  A61K9/16 ,  A61K31/565 ,  A61K31/4164 ,  A61K31/7056 ,  A61K31/4174 ,  A61K31/327 ,  A61K31/05 ,  A61K31/203 ,  A61K45/06 ,  A61K47/02 ,  A61K9/06 ,  A61K9/14 ,  A61K31/192 ,  A61K31/4436

CPC classification number: A61K9/0034 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/143 ,  A61K9/1611 ,  A61K31/05 ,  A61K31/192 ,  A61K31/203 ,  A61K31/327 ,  A61K31/4164 ,  A61K31/4174 ,  A61K31/4436 ,  A61K31/565 ,  A61K31/7056 ,  A61K45/06 ,  A61K47/02

Abstract: Topical vaginal compositions are disclosed herein which include silica microspheres and an active ingredient in the amount of 0.001 to 15.0% w/w selected from estradiol, metronidazole, clindamycin, butoconazole, and combinations thereof. The topical compositions provide sustained release of the active ingredient so as to reduce skin irritation.

公开(公告)号：US10780046B2

公开(公告)日：2020-09-22

申请号：US16386983

申请日：2019-04-17

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Marina Shevachman ,  Amira Ze'Evi ,  Eilon Asculai ,  Batella Binyaminovich ,  Nir Avram ,  Chaim Aschkenasy

IPC: A61K9/00 ,  A61K9/16 ,  A61K31/565 ,  A61K31/4164 ,  A61K31/7056 ,  A61K31/4174 ,  A61K31/327 ,  A61K31/05 ,  A61K31/203 ,  A61K45/06 ,  A61K47/02 ,  A61K9/06 ,  A61K9/14 ,  A61K31/192 ,  A61K31/4436

Abstract: Topical vaginal compositions are disclosed herein which include silica microspheres and an active ingredient in the amount of 0.001 to 15.0% w/w selected from estradiol, metronidazole, clindamycin, butoconazole, and combinations thereof. The topical compositions provide sustained release of the active ingredient so as to reduce skin irritation.