公开(公告)号：US20210130376A1

公开(公告)日：2021-05-06

申请号：US17146729

申请日：2021-01-12

申请人： SOOCHOW UNIVERSITY

发明人： Jianping ZOU ,  Dongliang ZHANG ,  Chengkun LI ,  Guoyu ZHANG ,  Zekun TAO

IPC分类号： C07F9/38 ,  B01J25/02

摘要： A method for preparing a β-amino phosphonic acid derivative includes: dissolving N-(arylvinyl)benzamide, dialkyl phosphite, manganese acetate, and potassium carbonate in a solvent and reacting at room temperature to obtain (2-benzamido-1-arylvinyl)dialkyl-phosphonate derivative; and hydrolyzing (2-benzamido-1-arylethyl) dialkylphosphonate derivative to obtain β-amino phosphonic acid derivative. The N-(arylvinyl) benzamide derivative is used as starting material. The raw materials are easy to obtain and are of many different types. A method of preparing β-aminophosphonic acid derivative includes: dissolving N-(arylvinyl)benzamide, dialkyl phosphite, manganese acetate and potassium carbonate in a solvent, reacting at room temperature to obtain (2-benzamide-1-arylvinyl) dialkyl phosphonate derivative, and then reducing and hydrolyzing the compound to obtain β-aminophosphonic acid derivative. The method of the invention has the advantages of short synthesis route, mild reaction conditions, simple reaction operation and post-treatment process, good yield, and is suitable for large-scale production.

公开(公告)号：US20210221831A1

公开(公告)日：2021-07-22

申请号：US17226213

申请日：2021-04-09

申请人： SOOCHOW UNIVERSITY

发明人： Jianping ZOU ,  Chengkun LI ,  Dongliang ZHANG ,  Zekun TAO ,  Jianan LI

IPC分类号： C07F9/40

摘要： Disclosed are a trifluoromethyl alkenylphosphonate derivative and preparation method therefor. The preparation method comprises the following steps: dissolving an acetylene derivative, an iodine compound, and a phosphorus reagent in a solvent for reaction at the temperature from the room temperature to 100° C. to obtain the trifluoromethyl alkenylphosphonate derivative. In the present invention, the acetylene derivative is used as a starting material, and the raw materials are easily available and diversified; products obtained by using the method of the present invention have various types and can be directly used and also used for other further reactions; moreover, the method disclosed in the present invention has the advantages of short steps, mild reaction conditions, simple reaction operation and post-treatment processes, and high yield, and is suitable for large-scale production.

公开(公告)号：US20210130377A1

公开(公告)日：2021-05-06

申请号：US17146466

申请日：2021-01-11

申请人： SOOCHOW UNIVERSITY

发明人： Jianping ZOU ,  Dongliang ZHANG ,  Chengkun LI ,  Guoyu ZHANG ,  Zekun TAO

IPC分类号： C07F9/50 ,  B01J23/44

摘要： The present invention discloses the preparation method of β-phosphonyl-enamine derivative. The preparation method comprising the following steps: dissolving the enamine derivative, organic phosphine compound, manganese acetate and potassium carbonate in the solvent, reacting at room temperature to obtain the β-phosphonyl-enamine derivative. The enamine derivative was as the starting material, and the raw materials are easy to obtain and a great many varieties. The various forms of the products obtained therein can be directly applied and can be used in further reactions. The reaction conditions are mild, the reaction speed is high, the reaction operation and the post-treatment process are simple, the production is convenient, and the method is suitable for large-scale production.