专利检索 ap:("SORBONNE UNIVERSITE" OR "CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE" OR "INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)") AND inv:"Xavier Guillonneau" 第 1 页

1.

发明授权
Agents that activate CD47 and their use in the treatment of inflammation 有权

公开(公告)号：US11142548B2

公开(公告)日：2021-10-12

申请号：US16300438

申请日：2017-05-10

申请人： SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)

发明人： Florian Sennlaub , Michael Housset , Xavier Guillonneau , José-Alain Sahel , Philippe Karoyan

IPC分类号： A61K38/00 , C07K7/08 , A61K38/16 , A61P27/02 , A61P29/00

摘要： Disclosed are agents activating CD47 and their use in the treatment of inflammation, in particular non-resolving low grade inflammation, characterized by chronic MP infiltration, such as age-related macular degeneration. Also disclosed are pharmaceutical compositions, medicaments and kits including the agents.

2.

发明授权
Agents that inhibit the binding of CFH to CD11 b/CD18 and uses thereof 有权

公开(公告)号：US11072661B2

公开(公告)日：2021-07-27

申请号：US16066015

申请日：2016-12-23

申请人： SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSERM (Institut National de la Santé et de la Recherche Médicale)

发明人： Florian Sennlaub , Bertrand Callippe , Xavier Guillonneau , José-Alain Sahel

IPC分类号： A61K39/00 , C07K16/28 , A61P27/02 , A61P29/00 , A61K9/00

摘要： Disclosed are agents inhibiting the interaction between CFH and CD11b/18, as well as the use of such agents, in particular for treating inflammatory disorders, such as age-related macular degeneration.

3.

发明授权
Lebecetin, a C-type lectin, as neovascularization inhibitor 有权

公开(公告)号：US11191807B2

公开(公告)日：2021-12-07

申请号：US16468305

申请日：2017-12-12

申请人： SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , INSTITUT PASTEUR DE TUNIS

发明人： Xavier Guillonneau , Fadoua Montassar , Naziha Marrakchi , Erij Messadi , Florian Sennlaub , José-Alain Sahel

IPC分类号： A61K38/17 , C12N15/86 , C07K14/46 , C07K14/705 , A61K38/18 , A61P27/02 , A61P35/00

摘要： The present invention relates to lebecetin, a functional variant or fragment thereof, for use as neovascularization inhibitor, in particular in the treatment of neovascular diseases such as ocular diseases, cancers or inflammatory disorders with a neovascular component.

4.

发明授权
Agents for use in the treatment of retinal inflammation 有权

公开(公告)号：US10519232B2

公开(公告)日：2019-12-31

申请号：US15111986

申请日：2015-01-22

申请人： Sorbonne Universite , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： Florian Sennlaub , Xavier Guillonneau , Olivier Levy , José-Alain Sahel

IPC分类号： A61K39/395 , A61K38/00 , C07K16/24 , C07K16/28

摘要： The present invention relates to preventive and/or therapeutic agents for use in the treatment of retinal inflammation, and more specifically of Age-related macular degeneration and Retinitis pigmentosa, wherein said agents are selected from an IL-6 inhibitor, an APOE inhibitor and/or a Fas activator as an active ingredient.