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公开(公告)号：US11191807B2
公开(公告)日：2021-12-07
申请号：US16468305
申请日：2017-12-12
申请人： SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , INSTITUT PASTEUR DE TUNIS
发明人： Xavier Guillonneau , Fadoua Montassar , Naziha Marrakchi , Erij Messadi , Florian Sennlaub , José-Alain Sahel
摘要： The present invention relates to lebecetin, a functional variant or fragment thereof, for use as neovascularization inhibitor, in particular in the treatment of neovascular diseases such as ocular diseases, cancers or inflammatory disorders with a neovascular component.
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公开(公告)号：US11717513B2
公开(公告)日：2023-08-08
申请号：US15777078
申请日：2016-11-17
申请人： SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
发明人： Valérie Fontaine , Cécile Vidal , José-Alain Sahel
IPC分类号： A61K31/426 , A61K9/00 , A61P27/02
CPC分类号： A61K31/426 , A61K9/0048 , A61K9/0053 , A61P27/02
摘要： Disclosed is a method utilizing (R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetic acid anilide or an analogue, pharmaceutically acceptable salt or solvate thereof for the treatment of a retinal disease, more specifically using mirabegron for the treatment of age-related macular degeneration. Also Disclosed is a pharmaceutical composition, a medicament and a kit for the treatment of age-related macular degeneration.
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公开(公告)号：US11080523B2
公开(公告)日：2021-08-03
申请号：US16331808
申请日：2017-09-08
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , SORBONNE UNIVERSITE
发明人： Kevin Gehere , Germain Haessig , Ryad Benosman , Sio Hoi Ieng , José-Alain Sahel , Guillaume Chenegros , Nicolas Libert
摘要： Disclosed is a method for pattern recognition in a plurality of received time signals of different types, the method includes: b) for each received signal, creating an asynchronous time signal including events; c) for each created asynchronous signal, creating an activity profile of the asynchronous signal which decreases as a function of the time elapsed since the last event of the asynchronous signal; d) for a given time t0: d1) determining a context defined as the set of activity profiles of the created asynchronous signals, d2) determining a standard context among predetermined standard contexts, having a minimum distance to the context determined in step d1, d3) determining the pattern as a function of the determined standard context.
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公开(公告)号：US20210002607A1
公开(公告)日：2021-01-07
申请号：US16976581
申请日：2019-03-06
申请人： SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
IPC分类号： C12N5/0793
摘要： The disclosure pertains to a defined cell culture medium for the expansion of human retinal progenitors, comprising or consisting of a nutrient medium, a SHH-pathway activator and a GSK3 inhibitor. To the use of the defined cell culture medium for the expansion of retinal progenitors, as well as to an in vitro method for expanding retinal progenitors, comprising: (i) placing a culture of human retinal progenitors in a defined cell culture medium as defined in claims 1 to 8; and (ii) culturing the cells in said defined cell culture medium.
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公开(公告)号：US20240092858A1
公开(公告)日：2024-03-21
申请号：US18255951
申请日：2020-12-08
申请人： SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM)
发明人： Christina Zeitz , Deniz Dalkara , Juliette Varin , Isabelle Audo , Serge Picaud , José-Alain Sahel
IPC分类号： C07K14/705 , A61K48/00 , A61P27/02 , C12N15/86
CPC分类号： C07K14/70503 , A61K48/0058 , A61P27/02 , C12N15/86 , C12N2750/14143 , C12N2830/008 , C12N2830/48
摘要： The present invention relates to an expression cassette allowing expression of a functional LRIT3 protein in mammal eyes; said expression cassette is inserted in an expression vector, preferably an adeno-associated virus (AAV); accordingly, the present invention further relates to a recombinant adeno-associated virus (AAV) vector carrying a nucleic acid sequence encoding a normal LRIT3 gene, or fragment thereof, under the control of regulatory sequences which express the product of the gene in the ocular cells, a pharmaceutically acceptable composition comprising such a recombinant AAV vector and to its use for the treatment of congenital stationary night blindness
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公开(公告)号：US11142548B2
公开(公告)日：2021-10-12
申请号：US16300438
申请日：2017-05-10
申请人： SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
摘要： Disclosed are agents activating CD47 and their use in the treatment of inflammation, in particular non-resolving low grade inflammation, characterized by chronic MP infiltration, such as age-related macular degeneration. Also disclosed are pharmaceutical compositions, medicaments and kits including the agents.
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公开(公告)号：US11072661B2
公开(公告)日：2021-07-27
申请号：US16066015
申请日：2016-12-23
申请人： SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSERM (Institut National de la Santé et de la Recherche Médicale)
摘要： Disclosed are agents inhibiting the interaction between CFH and CD11b/18, as well as the use of such agents, in particular for treating inflammatory disorders, such as age-related macular degeneration.
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公开(公告)号：US10519232B2
公开(公告)日：2019-12-31
申请号：US15111986
申请日：2015-01-22
IPC分类号： A61K39/395 , A61K38/00 , C07K16/24 , C07K16/28
摘要： The present invention relates to preventive and/or therapeutic agents for use in the treatment of retinal inflammation, and more specifically of Age-related macular degeneration and Retinitis pigmentosa, wherein said agents are selected from an IL-6 inhibitor, an APOE inhibitor and/or a Fas activator as an active ingredient.
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公开(公告)号：US10668129B2
公开(公告)日：2020-06-02
申请号：US15576027
申请日：2016-05-20
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS , UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： Thierry Leveillard , John Flannery , Xin Mei , Leah Byrne , José-Alain Sahel , Emmanuelle Clerin-Lachapelle , Junwei Sun , Jean Bennett , Jeannette Bennicelli
摘要： The present invention relates to the synergistic combination of the short and long Rod-Derived Cone Viability Factors and to methods for treating retinal degenerative diseases.
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10.发明授权公开(公告)号：US09994815B2
公开(公告)日：2018-06-12
申请号：US14786427
申请日：2014-04-25
申请人： UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
IPC分类号： C12N5/00 , C12N5/071 , C12N5/079 , C12N5/0793 , C12N5/0797
CPC分类号： C12N5/0621 , C12N5/062 , C12N5/0623 , C12N2501/115 , C12N2501/42 , C12N2502/1323 , C12N2506/03 , C12N2527/00 , C12N2533/54
摘要： A method for in vitro obtaining human retinal progenitors, includes the steps of (i) placing an adherent culture of human pluripotent stem cells in a pro-neural medium; and (ii) maintaining this culture in the pro-neural medium until the appearance of pigmented cells and/or of neuroepithelial-like structures. Additional steps can be performed to obtain RPE cells and/or precursors of the neural retina.
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