公开(公告)号：US20190225649A1

公开(公告)日：2019-07-25

申请号：US16300438

申请日：2017-05-10

申请人： SORBONNE UNIVERSITE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)

发明人： Florian SENNLAUB ,  Michael HOUSSET ,  Xavier GUILLONNEAU ,  José-Alain SAHEL ,  Philippe KAROYAN

IPC分类号： C07K7/08 ,  A61P29/00 ,  A61P27/02

摘要： Disclosed are agents activating CD47 and their use in the treatment of inflammation, in particular non-resolving low grade inflammation, characterized by chronic MP infiltration, such as age-related macular degeneration. Also disclosed are pharmaceutical compositions, medicaments and kits including the agents.

公开(公告)号：US20190010235A1

公开(公告)日：2019-01-10

申请号：US16066015

申请日：2016-12-23

申请人： SORBONNE UNIVERSITE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSERM (Institut National de la Santé et de la Recherche Médicale)

发明人： Florian SENNLAUB ,  Bertrand CALLIPPE ,  Xavier GUILLONNEAU ,  José-Alain SAHEL

IPC分类号： C07K16/28 ,  A61P29/00 ,  A61P27/02 ,  A61K9/00

摘要： Disclosed are agents inhibiting the interaction between CFH and CD11b/18, as well as the use of such agents, in particular for treating inflammatory disorders, such as age-related macular degeneration.

公开(公告)号：US20160340424A1

公开(公告)日：2016-11-24

申请号：US15111986

申请日：2015-01-22

申请人： UNIVERSITÉ PIERRE ET MARIE CURIE - PARIS 6 (UPMC) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Florian SENNLAUB ,  Xavier GUILLONNEAU ,  Olivier LEVY ,  José-Alain SAHEL

IPC分类号： C07K16/24 ,  C07K16/28

CPC分类号： C07K16/248 ,  A61K45/00 ,  C07K16/2866 ,  C07K2317/76

摘要： The present invention relates to preventive and/or therapeutic agents for use in the treatment of retinal inflammation, and more specifically of Age-related macular degeneration and Retinitis pigmentosa, wherein said agents are selected from an IL-6 inhibitor, an APOE inhibitor and/or a Fas activator as an active ingredient.

摘要翻译： 本发明涉及用于治疗视网膜炎症的预防和/或治疗剂，更具体地涉及年龄相关性黄斑变性和色素性视网膜炎，其中所述药剂选自IL-6抑制剂，APOE抑制剂和/ 或Fas活化剂作为活性成分。