公开(公告)号：US20240208950A1

公开(公告)日：2024-06-27

申请号：US18292049

申请日：2022-07-07

Applicant: SOUTH DAKOTA BOARD OF REGENTS

Inventor： Fathi T. HALAWEISH ,  Subhash CHAUHAN ,  Mena JAGGI

IPC: C07D405/12 ,  A61K31/4025 ,  A61P35/00

CPC classification number: C07D405/12 ,  A61K31/4025 ,  A61P35/00

Abstract: Provided are compositions and methods of using an anticancer agent for cancers, such as, ovarian and cervical cancer. The compositions and methods include ormeloxifene derivatives, a selective estrogen receptor modulator (SERM), for the treatment of ovarian and cervical cancers. The compositions and methods include various spectroscopy techniques and molecular modeling to produce derivative molecules comprising the ormeloxifene skeleton to enhance binding to key receptors implicated in cancer compared to ormeloxifene alone. The compositions and methods provide for reduced tumor volume and tumor weight compared to a placebo control.