PHYSIOLOGICALLY-RELEVANT, SERUM-FREE IN VITRO ANGIOGENESIS PLATFORM

    公开(公告)号:US20250084356A1

    公开(公告)日:2025-03-13

    申请号:US18725006

    申请日:2023-01-06

    Abstract: A custom platform is developed that is capable of culturing endothelial cells three-dimensionally while inducing physiological stimuli on the cells. A model includes serum-free conditions, allowing more quantifiable angiogenesis studies that investigate the dose dependent effects of various growth factors. Angiogenesis plays a critical role during development, wound healing, and disease; therefore, further investigation of the pathway has broad implications. Also, the development of in vitro vascularized tissue models via angiogenesis provides the ability to investigate endothelial responses after exposure to nanoparticles and mechanisms of drug delivery.

    Stimuli responsive microsphere composites

    公开(公告)号:US12188926B2

    公开(公告)日:2025-01-07

    申请号:US16518489

    申请日:2019-07-22

    Abstract: An event detection composite in embodiments of the present invention may have one or more of the following features: (a) a plurality of solid and/or hollow and/or porous-wall microspheres, (b) a functional material disposed on or within the plurality of microspheres, wherein the functional material can have unique optical, electrical, magnetic, thermal, or chemical properties, where these properties can be realized upon the plurality of microspheres being exposed to a physical, optical, electrical, magnetic, thermal or chemical stimuli, and (c) a host matrix containing the plurality of microspheres.

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