公开(公告)号：US12222305B1

公开(公告)日：2025-02-11

申请号：US18727344

申请日：2024-02-06

Applicant: SOUTHEAST UNIVERSITY

Inventor： Zhen Zhu ,  Song Yu ,  Jianwei Ouyang

IPC: G01N27/02 ,  B01L3/00 ,  H05K1/18

Abstract: Disclosed are an electrical impedance monitoring device, system and method for locomotion behaviors of C. elegans. A microfluidic channel layer and a gas channel layer form a double-layer structure by bonding, and the double-layer structure is tightly fixed to a circuit board with nylon screws. An electrode array configured as a concentric circle structure is arranged on the circuit board and used for realizing EIT monitoring of C. elegans. The microfluidic channel layer comprises a culture and monitoring chamber and a C. elegans transition channel and used for long-term culture and cyclic monitoring of C. elegans. The gas channel layer comprises a gas inlet and a gas channel and used for applying a gas pressure to squeeze an upper wall of the microfluidic channel layer to form a membrane valve to close the microfluidic channel layer.