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公开(公告)号：US11249003B2
公开(公告)日：2022-02-15
申请号：US17270052
申请日：2020-04-26
Applicant: Southeast University
Inventor： Zhen Zhu , Mi Wang , Zhao Zhang , Qingan Huang
IPC: G01N15/10
Abstract: Disclosed is a passive wireless device for microfluidic detection of multi-level droplets. A primary inductor channel and a secondary inductor channel each comprise two layers of inductance coils, and the inductance coils of the primary inductor channel and the secondary inductor channel are alternately arranged in each layer. A double-resonance circuit is formed after a liquid conductive material is injected. A first part of a detection channel is disposed between a primary capacitor channel, and a second part of a detection channel is disposed between a secondary capacitor channel. A reading device is used to read a resonant frequency of the double-resonance circuit, and perform detection according to the resonant frequency to obtain information of a corresponding first droplet group and/or second droplet group.
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公开(公告)号：US12222305B1
公开(公告)日：2025-02-11
申请号：US18727344
申请日：2024-02-06
Applicant: SOUTHEAST UNIVERSITY
Inventor： Zhen Zhu , Song Yu , Jianwei Ouyang
Abstract: Disclosed are an electrical impedance monitoring device, system and method for locomotion behaviors of C. elegans. A microfluidic channel layer and a gas channel layer form a double-layer structure by bonding, and the double-layer structure is tightly fixed to a circuit board with nylon screws. An electrode array configured as a concentric circle structure is arranged on the circuit board and used for realizing EIT monitoring of C. elegans. The microfluidic channel layer comprises a culture and monitoring chamber and a C. elegans transition channel and used for long-term culture and cyclic monitoring of C. elegans. The gas channel layer comprises a gas inlet and a gas channel and used for applying a gas pressure to squeeze an upper wall of the microfluidic channel layer to form a membrane valve to close the microfluidic channel layer.
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公开(公告)号：US11661573B2
公开(公告)日：2023-05-30
申请号：US16960239
申请日：2018-04-04
Applicant: SOUTHEAST UNIVERSITY
Inventor： Zhen Zhu , Qiaodan Li , Dingxin Jin , Feng Yu , Yangye Geng
CPC classification number: C12M21/08 , B01L3/50273 , C12M23/16 , C12M41/46 , B01L2300/0645 , B01L2300/0864 , B01L2400/0475
Abstract: A microfluidic chip for culturing and real-time monitoring of multicellular tissues and use method thereof. The chip comprises a glass substrate layer, and a PDMS microchannel layer located on the glass substrate layer, wherein the glass substrate layer comprises a glass substrate, and a plurality of microelectrodes thereon; the PDMS microchannel comprises a plurality of independent microfluidic channels; the microelectrodes on the glass substrate are in one-to-one correspondence with the microfluidic channels in the PDMS microchannel layer; and the microelectrodes are electrically connected to an external circuit. The use method comprises: cell capture, cell or tissue culture, electrical impedance spectroscopy detection, and tissue release.
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公开(公告)号：US11408845B2
公开(公告)日：2022-08-09
申请号：US17270050
申请日：2020-04-26
Applicant: Southeast University
Inventor： Zhen Zhu , Mi Wang , Yingying Wang , Qingan Huang
Abstract: Disclosed a passive wireless sensor for detecting discrete droplets and bubbles. A first inductor channel and a second inductor channel are disposed opposite each other to form a capacitor channel, the first inductor channel is connected to the second inductor channel to form a resonant circuit. When a detection object passes through the detection channel, the permittivity between the first inductor channel and the second inductor channel changes and consequently a capacitance value of the capacitor channel changes, thus resulting in a change in resonant frequency of the resonant circuit. A readout device is used to read the resonant frequency of the resonant circuit and perform detection according to the resonant frequency to obtain information of a corresponding detection object.
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