公开(公告)号：US12275686B2

公开(公告)日：2025-04-15

申请号：US18812980

申请日：2024-08-22

Applicant: SOUTHEAST UNIVERSITY

Inventor： Shaohua Gou ,  Wanxiang Yang

IPC: C07C243/04 ,  A61K31/196 ,  A61P9/10

Abstract: Disclosed is NO donor compound and preparation method, pharmaceutical composition, and use. The compound has a structure represented by formula The NO donor compound and the pharmaceutical composition thereof, as hypoxia-activated NO donors, may be prepared as drugs for treating myocardial hypoxic damage disease. The prepared drugs can exert efficacy at both the cellular level and the animal level, and the synthesis method of the compound is simple and easy to operate.

公开(公告)号：US09227991B2

公开(公告)日：2016-01-05

申请号：US14437809

申请日：2013-08-29

Applicant: SOUTHEAST UNIVERSITY

Inventor： Shaohua Gou

IPC: C07C49/92 ,  C07F15/00 ,  A61K31/282

CPC classification number: C07F15/0093 ,  A61K31/282 ,  C07F15/00 ,  C07F15/0066

Abstract: Platinum complexes containing 3-ketone cyclobutane 1,1-dicarboxylic acid as leaving group for treating cancers and a preparation method of the complexes, one of the platinum complexes is cis-[3-ketone cyclobutane-1,1-dicarboxylic acid radical.diamineplatinum (II)], GSH-5 for short, the chemical structure formula is expressed by formula (1). The other platinum complex is cis-[3-ketone-cyclobutane-1,1-dicarboxylic acid radical.trans-1,2-cyclohexanediamineplatinum (II)], GSH-6 for short, the chemical structure formula is expressed by formula (2). In the formula (2), two chiral carbon atoms marked with * in the trans-1,2-cyclohexanediamine group are both of R forms or S forms.

Abstract translation: 含有3-酮环丁烷1,1-二羧酸作为离去基团用于治疗癌症的铂络合物和铂络合物的制备方法之一是顺式 - [3-酮环丁烷-1,1-二羧酸基团二氨基铂 （II）]，GSH-5，化学结构式由式（1）表示。 其他铂络合物是顺式 - [3-酮 - 环丁烷-1,1-二羧酸基团，反式-1,2-环己烷二氨基铂（II）]，GSH-6，化学结构式由式 ）。 在式（2）中，在反式-1,2-环己二胺基中标有*的两个手性碳原子都是R形或S形。