公开(公告)号：US10065933B2

公开(公告)日：2018-09-04

申请号：US15528281

申请日：2015-12-28

申请人： ST PHARM CO., LTD.

发明人： Geun Jho Lim ,  Sun Ki Chang ,  Chang Ho Byeon ,  Hoe Jin Yoon ,  Moon Soo Kim

IPC分类号： C07D257/02 ,  C07F5/00 ,  A61K49/10

摘要： The present disclosure relates to a novel method for preparing high-purity gadobutrol. The present disclosure can be easily applied to a large scale production because purity of intermediate can be managed via simple and mild process and accordingly, high-purity or ultra high-purity gadobutrol that has higher purity than previous gadobutrol can be prepared in high yield therethrough.

公开(公告)号：US09822084B2

公开(公告)日：2017-11-21

申请号：US15511882

申请日：2015-09-07

申请人： ST PHARM CO., LTD.

发明人： Geun Jho Lim ,  Sun Ki Chang ,  Chang Ho Byeon ,  Hoe Jin Yoon ,  Moon Soo Kim

IPC分类号： C07D257/02

CPC分类号： C07D257/02 ,  C07F3/04

摘要： Disclosed is a novel method of preparing highly pure calcobutrol using an intermediate (butrol) of gadobutrol without using highly pure gadobutrol. This method is capable of obtaining calcobutrol at high purity and high yield through a simple and environmentally friendly process, and thus can be easily applied to mass production.