公开(公告)号：US20200377498A1

公开(公告)日：2020-12-03

申请号：US16497255

申请日：2017-03-24

申请人： ST PHARM CO., LTD.

发明人： Bong Jin KIM ,  Ill Young LEE ,  Jae Hak KIM ,  Hong Suk SHIN ,  Jong Chan SON ,  Chong-Kyo LEE ,  Kyungjin KIM ,  Uk-Il KIM ,  Hwa Jung NAM

IPC分类号： C07D471/04 ,  A61P31/18

摘要： Provided is a novel pyrrolopyridine compound represented by Chemical Formula I, a racemate or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof; and to a method for preparing the same. A compound represented by Chemical Formula I shows high selectivity and antiviral activity against human immunodeficiency virus (HIV), with low toxicity; therefore, it is useful as a therapeutic agent for viral infection, in particular, HIV infection.

公开(公告)号：US10428096B2

公开(公告)日：2019-10-01

申请号：US14906233

申请日：2014-07-16

申请人： HYOSUNG CHEMICAL CORPORATION ,  ST PHARM CO., LTD.

发明人： Jae Yoon Shim ,  Sun Kue Kim ,  Hae Souk Cho ,  Ji Hwan Choi ,  Geun Jho Lim ,  Sun Ki Chang ,  Min Kyu Kim ,  In Hyeok Baek

IPC分类号： C07F9/00 ,  C07F9/655 ,  C07F9/50 ,  C08G67/02

摘要： Provided are a novel polyketone polymerization catalyst and a method of preparing a ligand, which can reduce production costs and can enable commercial mass synthesis by using ((2,2-dimethyl-1,3-dioxane-5,5-diyl)bis(methylene))bis(bis(2-methoxyphenyl)phosphine) as a ligand constituting the polykeytone polymerization catalyst, the ligand having a simple structure and a small molecular weight while having high activity.

公开(公告)号：US20180361369A1

公开(公告)日：2018-12-20

申请号：US15781334

申请日：2016-11-11

申请人： ST PHARM CO., LTD.

发明人： Geun Jho Lim ,  Sun Ki Chang ,  Hyun Woo Baek ,  Jun Hyun Oh ,  Yeong Hun Kim

IPC分类号： B01J31/02 ,  C07F9/50

摘要： The present disclosure provides a method for preparing ((2,2-dimethyl-1,3-dioxane-5,5-diyl)bis(methylene))bis(bis(2-methoxyphenyl)phosphine), a ligand for a polyketone polymerization catalyst, under mild conditions with high purity and high yield. Therefore, the preparation method of the present disclosure can be easily applied to mass production.

公开(公告)号：US20180346443A1

公开(公告)日：2018-12-06

申请号：US16060655

申请日：2016-12-09

申请人： ST PHARM CO., LTD.

发明人： Seok Hun Woo ,  YunHee Choi ,  Hong Jun Kim ,  Sun Ki Chang ,  Geun Jho Lim

IPC分类号： C07D401/04

摘要： Disclosed is a method of preparing an intermediate for an oxazolidinone derivative, which enables 5-bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine to be produced at high yield and high purity, thus exhibiting high preparation efficiency under optimal processing conditions and making it suitable for industrial mass production.

公开(公告)号：US20170342038A1

公开(公告)日：2017-11-30

申请号：US15528281

申请日：2015-12-28

申请人： ST PHARM CO., LTD.

发明人： Geun Jho LIM ,  Sun Ki CHANG ,  Chang Ho BYEON ,  Hoe Jin YOON ,  Moon Soo Kim

IPC分类号： C07D257/02 ,  C07F5/00 ,  A61K49/10

CPC分类号： C07D257/02 ,  A61K49/106 ,  C07F5/003

摘要： The present disclosure relates to a novel method for preparing high-purity gadobutrol. The present disclosure can be easily applied to a large scale production because purity of intermediate can be managed via simple and mild process and accordingly, high-purity or ultra high-purity gadobutrol that has higher purity than previous gadobutrol can be prepared in high yield therethrough.

公开(公告)号：US09790170B2

公开(公告)日：2017-10-17

申请号：US15034536

申请日：2014-10-27

申请人： ST PHARM CO., LTD.

发明人： Geun Jho Lim ,  Sun Ki Chang ,  Jae Hun Kim ,  Jong Moon Park

IPC分类号： C07C231/12 ,  C07C231/02 ,  B01J23/04

CPC分类号： C07C231/12 ,  B01J23/04 ,  C07C231/02 ,  C07C233/47 ,  C07C237/22

摘要： The present invention provides a novel method for preparing lacosamide with high chiral purity from D-serine. The method of the present invention can obtain lacosamide with high chiral purity in a high yield through a simple and environmentally-friendly process and thus can be easily applied to mass production.

公开(公告)号：US20170166572A1

公开(公告)日：2017-06-15

申请号：US15325692

申请日：2015-07-10

申请人： ST PHARM CO., LTD.

发明人： Jung Nyoung HEO ,  Hwan Jung LIM ,  Kwang Rok KIM ,  Kyung Jin KIM ,  Uk Il KIM ,  Hyung Tae BANG ,  Ji Hye YOON

IPC分类号： C07D487/04

CPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K31/53 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14

摘要： The present invention relates to a novel imidazotriazinone or imidazopyrazinone derivative, a tautomer thereof, a stereoisomer thereof and their mixture, or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition for preventing or treating a tankyrase-related disease, which contains the same as an active ingredient.

公开(公告)号：US11149033B2

公开(公告)日：2021-10-19

申请号：US16338237

申请日：2017-09-29

申请人： INSTITUT PASTEUR KOREA ,  ST PHARM CO., LTD.

发明人： Ji Young Min ,  So Young Chang ,  Ji Hye Lee ,  Sun Hee Kang ,  Sun Ju Kong ,  Su Yeon Jo ,  Young Mi Kim ,  Junghwan Choi

IPC分类号： C07D413/06 ,  C07D263/46 ,  C07D271/10 ,  C07D271/113 ,  C07D307/64 ,  C07D405/06

摘要： The present invention relates to a novel heteroaryl compound, an enantiomer, a diastereomer or a pharmaceutically acceptable salt thereof, and an antiviral composition comprising the same as an active ingredient. The novel compounds represented by formula (I) or formula (II) according to the present invention are remarkably superior in antiviral activity against an influenza virus, and furthermore, have low cytotoxicity and thus low adverse effects on a human body. Therefore, a pharmaceutical composition containing the same as an active ingredient can be effectively used for the prevention or treatment of diseases caused by an influenza virus infection.

公开(公告)号：US20210317142A1

公开(公告)日：2021-10-14

申请号：US17270268

申请日：2019-08-23

申请人： ST PHARM CO., LTD.

发明人： Changho BYEON ,  Hoejin YOON ,  Moonsu KIM ,  Seongsu JEONG ,  Jongmoon PARK ,  Junwon LEE ,  Seokhun WOO ,  Sun Ki CHANG

IPC分类号： C07F5/00

摘要： The present invention provides a novel method for preparing high-purity gadobutrol or hydrates thereof. The preparation method of the present invention can have an advantage of simplifying a process by forming a gadolinium complex in-situ without purification of a butrol intermediate and omitting a resin purification process unlike a conventional method for synthesizing gadobutrol. In addition, the preparation method of the present invention can be used to produce high-purity gadobutrol or hydrates thereof at a high yield only through the simple process as above, and thus can be useful in mass production.

公开(公告)号：US10702859B2

公开(公告)日：2020-07-07

申请号：US15781334

申请日：2016-11-11

申请人： ST PHARM CO., LTD.

发明人： Geun Jho Lim ,  Sun Ki Chang ,  Hyun Woo Baek ,  Jun Hyun Oh ,  Yeong Hun Kim

IPC分类号： C07F9/655 ,  B01J31/02 ,  C07F9/50 ,  C08L61/34

摘要： The present disclosure provides a method for preparing ((2,2-dimethyl-1,3-dioxane-5,5-diyl)bis(methylene))bis(bis(2-methoxyphenyl)phosphine), a ligand for a polyketone polymerization catalyst, under mild conditions with high purity and high yield. Therefore, the preparation method of the present disclosure can be easily applied to mass production.