公开(公告)号：US20240124465A1

公开(公告)日：2024-04-18

申请号：US18256857

申请日：2021-12-17

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

Inventor： Jaeki Min ,  Jamie Jarusiewicz ,  Marisa Actis ,  Yunchao Chang ,  Lisa Alcock ,  Charles Mulligan ,  Zoran Rankovic

IPC: C07D487/04 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: The present disclosure relates to chemical compounds that modulate JAK-2 signaling, which are useful in the treatment of disorders associated with JAK-2 signaling dysfunction such as, for example, disorders of cellular proliferation (e.g., cancer) and autoimmune and inflammatory disorders, pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.