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公开(公告)号：US11446308B2
公开(公告)日：2022-09-20
申请号：US16707991
申请日：2019-12-09
Applicant: St. Jude Children's Research Hospital
Inventor： Jian Zuo , Tai Teitz , Jie Fang , Asli Goktug , Taosheng Chen , Jaeki Min , R. Kiplin Guy
IPC: A61K31/55 , A61K31/4015 , A61K31/454 , A61K31/404 , A61K31/506 , A61K31/52 , A61K31/519 , A61K31/4155 , A61P27/16
Abstract: In one aspect, pharmaceutical compositions comprising a CDK2 inhibitor and one or more of at least one agent known to treat a hearing impairment and at least one agent known to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20200179397A1
公开(公告)日：2020-06-11
申请号：US16707991
申请日：2019-12-09
Applicant: St. Jude Children's Research Hospital
Inventor： Jian Zuo , Tal Teitz , Jie Fang , Asli Goktug , Taosheng Chen , Jaeki Min , R. Kiplin Guy
IPC: A61K31/55 , A61K31/404 , A61K31/454 , A61K31/506 , A61K31/52 , A61P27/16
Abstract: In one aspect, pharmaceutical compositions comprising a CDK2 inhibitor and one or more of at least one agent known to treat a hearing impairment and at least one agent known to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US11883491B2
公开(公告)日：2024-01-30
申请号：US16610170
申请日：2018-04-30
Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
Inventor： Jian Zuo , Fei Zheng , Tetsuji Yamashita , Zoe Kellard , Tal Teitz , Jaeki Min , Taosheng Chen
IPC: A61K31/18 , A61K31/422 , A61K31/44 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/58 , A61K45/06 , A61K39/395 , A61P27/16 , A61K31/4706 , A61K31/4709 , A61K31/5377 , A61K31/713 , A61K38/17
CPC classification number: A61K39/3955 , A61K31/18 , A61K31/422 , A61K31/44 , A61K31/4706 , A61K31/4709 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/58 , A61K31/713 , A61K38/1709 , A61K45/06 , A61P27/16
Abstract: Methods and compositions using an inhibitor of EGFR signaling for prevention or an inhibitor of EGFR signaling and a nucleic acid molecule encoding an atonal-associated factor for treatment of hearing loss are described.
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公开(公告)号：US20180161340A1
公开(公告)日：2018-06-14
申请号：US15580224
申请日：2016-06-20
Applicant: St. Jude Children's Research Hospital
Inventor： Jian Zuo , Tai Teitz , Jie Fang , Asli Goktug , Taosheng Chen , Jaeki Min , R. Kiplin Guy
IPC: A61K31/55 , A61K31/52 , A61K31/404 , A61K31/506 , A61K31/454 , A61P27/16
CPC classification number: A61K31/55 , A61K31/404 , A61K31/454 , A61K31/506 , A61K31/52 , A61P27/16
Abstract: In one aspect, pharmaceutical compositions comprising a CDK2 inhibitor and one or more of at least one agent known to treat a hearing impairment and at least one agent known to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US11963954B2
公开(公告)日：2024-04-23
申请号：US17470678
申请日：2021-09-09
Inventor： Jaeki Min , Daniel C. Scott , Deepak Bhasin , Brenda A. Schulman , Bhuvanesh Singh , Jared T. Hammill , R. Kiplin Guy
IPC: A61K31/4545 , A61K31/17 , A61K31/437 , A61K31/451 , A61K31/4525 , A61K31/454 , A61K31/506 , A61P15/16 , A61P31/04 , A61P31/12 , C07D211/58 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/14 , C07D417/04 , C07D417/06 , C07D471/04
CPC classification number: A61K31/4545 , A61K31/17 , A61K31/437 , A61K31/451 , A61K31/4525 , A61K31/454 , A61K31/506 , A61P15/16 , A61P31/04 , A61P31/12 , C07D211/58 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/14 , C07D417/04 , C07D417/06 , C07D471/04
Abstract: In one aspect, the invention relates to substituted 1-phenyl-3-(piperidin-4-yl)urea analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the DCN1-UBC12 interaction inhibitors of DCN1-mediated cullin-RING ligase activity, methods of making same, pharmaceutical compositions comprising same, methods of treating disorders using the disclosed compounds and compositions, methods of treating disorders associated with a DCN1-UBC12 interaction dysfunction, methods of treating disorders associated with a DCN1-mediated cullin-RING ligase activity dysfunction, methods of male contraception comprising the disclosed compounds and compositions, and kits comprising the disclosed compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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Patent Agency Ranking
公开(公告)号：US20180291004A1
公开(公告)日：2018-10-11
申请号：US15812605
申请日：2017-11-14
Applicant: St. Jude Children's Research Hospital
Inventor： R. Kiplin Guy , Yiqun Zhang , Brandon Young , Michael Dyer , Kristin Finch , Donald Bashford , Nagakumar Bharatham , Richard Kriwacki , Grace Roy-Appa , Lie Min , Jaeki Min , Antonio Ferreira
IPC: C07D403/06 , C07D403/14 , C07D233/22
Abstract: The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20160297800A1
公开(公告)日：2016-10-13
申请号：US14991744
申请日：2016-01-08
Applicant: St. Jude Children's Research Hospital
Inventor： R. Kiplin Guy , Yiqun Zhang , Brandon Young , Michael Dyer , Kristin Finch , Donald Bashford , Nagakumar Bharatham , Richard Kriwacki , Grace Roy-Appa , Lie Min , Jaeki Min , Antonio Ferreira
IPC: C07D403/06
CPC classification number: C07D403/06 , C07D233/22 , C07D403/14
Abstract: The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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8.发明公开公开(公告)号：US20240124465A1
公开(公告)日：2024-04-18
申请号：US18256857
申请日：2021-12-17
Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
Inventor： Jaeki Min , Jamie Jarusiewicz , Marisa Actis , Yunchao Chang , Lisa Alcock , Charles Mulligan , Zoran Rankovic
IPC: C07D487/04 , C07D519/00
CPC classification number: C07D487/04 , C07D519/00
Abstract: The present disclosure relates to chemical compounds that modulate JAK-2 signaling, which are useful in the treatment of disorders associated with JAK-2 signaling dysfunction such as, for example, disorders of cellular proliferation (e.g., cancer) and autoimmune and inflammatory disorders, pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US11116757B2
公开(公告)日：2021-09-14
申请号：US16683076
申请日：2019-11-13
Inventor： Jaeki Min , Daniel C. Scott , Deepak Bhasin , Brenda A. Schulman , Bhuvanesh Singh , Jared T. Hammill , R. Kiplin Guy
IPC: A61K31/4545 , C07D401/12 , C07D211/58 , C07D401/06 , C07D409/14 , C07D405/12 , C07D417/06 , C07D471/04 , C07D405/06 , C07D401/04 , C07D417/04 , A61P31/12 , A61P15/16 , A61P31/04 , A61K31/17 , A61K31/437 , A61K31/451 , A61K31/4525 , A61K31/454 , A61K31/506
Abstract: In one aspect, the invention relates to substituted 1-phenyl-3-(piperidin-4-yl)urea analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the DCN1-UBC12 interaction inhibitors of DCN1-mediated cullin-RING ligase activity, methods of making same, pharmaceutical compositions comprising same, methods of treating disorders using the disclosed compounds and compositions, methods of treating disorders associated with a DCN1-UBC12 interaction dysfunction, methods of treating disorders associated with a DCN1-mediated cullin-RING ligase activity dysfunction, methods of male contraception comprising the disclosed compounds and compositions, and kits comprising the disclosed compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US09822100B2
公开(公告)日：2017-11-21
申请号：US14991744
申请日：2016-01-08
Applicant: St. Jude Children's Research Hospital
Inventor： R. Kiplin Guy , Yiqun Zhang , Brandon Young , Michael Dyer , Kristin Finch , Donald Bashford , Nagakumar Bharatham , Richard Kriwacki , Grace Roy-Appa , Lie Min , Jaeki Min , Antonio Ferreira
IPC: C07D403/06 , C07D403/14 , C07D233/22
CPC classification number: C07D403/06 , C07D233/22 , C07D403/14
Abstract: The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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