公开(公告)号：US10947203B2

公开(公告)日：2021-03-16

申请号：US16679007

申请日：2019-11-08

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

Inventor： Taosheng Chen ,  Wenwei Lin ,  Yueming Wang

IPC: A61K31/4192 ,  C07D249/06 ,  A61K9/20 ,  A61K47/02 ,  A61K9/00 ,  A61K47/10 ,  A61K47/36 ,  A61P35/00

Abstract: In an aspect, the invention relates to 1,4,5-substituted 1,2,3-triazole and 1,2,4,5-substituted imidazoles having a structure represented by a formula: which are modulators the pregnane X receptor (“PXR”); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of modulating an adverse drug reaction in a mammal using the compounds and pharmaceutical compositions; methods of treatment of a disorder of uncontrolled cellular proliferation, such as a cancer, using the compounds and pharmaceutical compositions; methods of modulating pregnane X receptor activity in a mammal using the compounds and pharmaceutical compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US10550091B2

公开(公告)日：2020-02-04

申请号：US16085972

申请日：2017-03-10

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

Inventor： Taosheng Chen ,  Wenwei Lin ,  Yueming Wang

IPC: C07D249/06 ,  A61K9/20 ,  A61K47/02 ,  A61K9/00 ,  A61K47/10 ,  A61K47/36 ,  A61P35/00

Abstract: In an aspect, the invention relates to 1,4,5-substituted 1,2,3-triazole and 1,2,4,5-substituted imidazoles, which are modulators the pregnane X receptor (“PXR”); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of modulating an adverse drug reaction in a mammal using the compounds and pharmaceutical compositions; methods of treatment of a disorder of uncontrolled cellular proliferation, such as a cancer, using the compounds and pharmaceutical compositions; methods of modulating pregnane X receptor activity in a mammal using the compounds and pharmaceutical compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20190077770A1

公开(公告)日：2019-03-14

申请号：US16085972

申请日：2017-03-10

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

Inventor： Taosheng CHEN ,  Wenwei Lin ,  Yueming Wang

IPC: C07D249/06

CPC classification number: C07D249/06 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/2018 ,  A61K9/205 ,  A61K9/2054 ,  A61K47/02 ,  A61K47/10 ,  A61K47/36 ,  A61P35/00

Abstract: In an aspect, the invention relates to 1,4,5-substituted 1,2,3-triazole and 1,2,4,5-substituted imidazoles, which are modulators the pregnane X receptor (“PXR”); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of modulating an adverse drug reaction in a mammal using the compounds and pharmaceutical compositions; methods of treatment of a disorder of uncontrolled cellular proliferation, such as a cancer, using the compounds and pharmaceutical compositions; methods of modulating pregnane X receptor activity in a mammal using the compounds and pharmaceutical compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.