-
公开(公告)号：US20170189477A1
公开(公告)日：2017-07-06
申请号：US15394375
申请日：2016-12-29
Applicant: St. Jude Children's Research Hospital
Inventor： Jian Zuo , Taosheng Chen , Brandon Walters , Bryan Kuo , Bradley Walters
CPC classification number: A61K38/1703 , A61K9/0046 , A61K31/05 , A61K31/222 , A61K31/44 , A61K31/4418 , A61K31/55 , A61K35/12 , A61K38/17 , A61K45/06 , C12N5/0602 , C12N5/062
Abstract: In one aspect, the invention relates to pharmaceutical compositions comprising agents that activate the expression of Atoh1, or pharmaceutically acceptable salts, solvates, or polymorphs thereof and agents that inhibit the expression of p27Kip1, or pharmaceutically acceptable salts, solvates, or polymorphs thereof, which are useful for inducing the formation of cochlear hair cells; and methods of treating hearing impairments or disorders using the compositions. In one aspect, the invention relates to pharmaceutical compositions comprising β-catenin; and agents that activate the expression of Atoh1, or pharmaceutically acceptable salts, solvates, or polymorphs thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
-
公开(公告)号：US11446308B2
公开(公告)日：2022-09-20
申请号：US16707991
申请日：2019-12-09
Applicant: St. Jude Children's Research Hospital
Inventor： Jian Zuo , Tai Teitz , Jie Fang , Asli Goktug , Taosheng Chen , Jaeki Min , R. Kiplin Guy
IPC: A61K31/55 , A61K31/4015 , A61K31/454 , A61K31/404 , A61K31/506 , A61K31/52 , A61K31/519 , A61K31/4155 , A61P27/16
Abstract: In one aspect, pharmaceutical compositions comprising a CDK2 inhibitor and one or more of at least one agent known to treat a hearing impairment and at least one agent known to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
-
公开(公告)号：US20200179397A1
公开(公告)日：2020-06-11
申请号：US16707991
申请日：2019-12-09
Applicant: St. Jude Children's Research Hospital
Inventor： Jian Zuo , Tal Teitz , Jie Fang , Asli Goktug , Taosheng Chen , Jaeki Min , R. Kiplin Guy
IPC: A61K31/55 , A61K31/404 , A61K31/454 , A61K31/506 , A61K31/52 , A61P27/16
Abstract: In one aspect, pharmaceutical compositions comprising a CDK2 inhibitor and one or more of at least one agent known to treat a hearing impairment and at least one agent known to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
-
公开(公告)号：US20160030445A1
公开(公告)日：2016-02-04
申请号：US14774597
申请日：2014-03-15
Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
Inventor： Jian Zuo , Taosheng Chen , Brandon Walters , Bryan Kuo , Bradley Walters
CPC classification number: A61K38/1703 , A61K9/0046 , A61K31/05 , A61K31/222 , A61K31/44 , A61K31/4418 , A61K31/55 , A61K35/12 , A61K38/17 , A61K45/06 , C12N5/0602 , C12N5/062
Abstract: In one aspect, the invention relates to pharmaceutical compositions comprising agents that activate the expression of Atoh1, or pharmaceutically acceptable salts, solvates, or polymorphs thereof; and agents that inhibit the expression of p27Kip1, or pharmaceutically acceptable salts, solvates, or polymorphs thereof, which are useful for inducing the formation of cochlear hair cells; and methods of treating hearing impairments or disorders using the compositions. In one aspect, the invention relates to pharmaceutical compositions comprising β-catenin; and agents that activate the expression of Atoh1, or pharmaceutically acceptable salts, solvates, or polymorphs thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Abstract translation: 一方面，本发明涉及包含活化Atoh1表达的试剂或其药学上可接受的盐，溶剂合物或多晶型物的药物组合物; 以及抑制p27Kip1或其药学上可接受的盐，溶剂合物或多晶型物的表达的试剂，其可用于诱导耳蜗毛细胞的形成; 以及使用该组合物治疗听力障碍或障碍的方法。 一方面，本发明涉及包含β-联蛋白的药物组合物; 以及激活Atoh1表达的药剂，或其药学上可接受的盐，溶剂化物或多晶型物。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
-
公开(公告)号：US11883491B2
公开(公告)日：2024-01-30
申请号：US16610170
申请日：2018-04-30
Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
Inventor： Jian Zuo , Fei Zheng , Tetsuji Yamashita , Zoe Kellard , Tal Teitz , Jaeki Min , Taosheng Chen
IPC: A61K31/18 , A61K31/422 , A61K31/44 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/58 , A61K45/06 , A61K39/395 , A61P27/16 , A61K31/4706 , A61K31/4709 , A61K31/5377 , A61K31/713 , A61K38/17
CPC classification number: A61K39/3955 , A61K31/18 , A61K31/422 , A61K31/44 , A61K31/4706 , A61K31/4709 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/58 , A61K31/713 , A61K38/1709 , A61K45/06 , A61P27/16
Abstract: Methods and compositions using an inhibitor of EGFR signaling for prevention or an inhibitor of EGFR signaling and a nucleic acid molecule encoding an atonal-associated factor for treatment of hearing loss are described.
-
Patent Agency Ranking
公开(公告)号：US20180161340A1
公开(公告)日：2018-06-14
申请号：US15580224
申请日：2016-06-20
Applicant: St. Jude Children's Research Hospital
Inventor： Jian Zuo , Tai Teitz , Jie Fang , Asli Goktug , Taosheng Chen , Jaeki Min , R. Kiplin Guy
IPC: A61K31/55 , A61K31/52 , A61K31/404 , A61K31/506 , A61K31/454 , A61P27/16
CPC classification number: A61K31/55 , A61K31/404 , A61K31/454 , A61K31/506 , A61K31/52 , A61P27/16
Abstract: In one aspect, pharmaceutical compositions comprising a CDK2 inhibitor and one or more of at least one agent known to treat a hearing impairment and at least one agent known to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
-
公开(公告)号：US09572815B2
公开(公告)日：2017-02-21
申请号：US14774597
申请日：2014-03-15
Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
Inventor： Jian Zuo , Taosheng Chen , Brandon Walters , Bryan Kuo , Bradley Walters
IPC: A61K31/55 , A61K45/06 , A61K31/05 , A61K31/222 , A61K31/4418 , A61K38/17 , A61K35/12 , A61K31/44 , C12N5/071
CPC classification number: A61K38/1703 , A61K9/0046 , A61K31/05 , A61K31/222 , A61K31/44 , A61K31/4418 , A61K31/55 , A61K35/12 , A61K38/17 , A61K45/06 , C12N5/0602 , C12N5/062
Abstract: In one aspect, the invention relates to pharmaceutical compositions comprising agents that activate the expression of Atoh1, or pharmaceutically acceptable salts, solvates, or polymorphs thereof; and agents that inhibit the expression of p27Kip1, or pharmaceutically acceptable salts, solvates, or polymorphs thereof, which are useful for inducing the formation of cochlear hair cells; and methods of treating hearing impairments or disorders using the compositions. In one aspect, the invention relates to pharmaceutical compositions comprising β-catenin; and agents that activate the expression of Atoh1, or pharmaceutically acceptable salts, solvates, or polymorphs thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Abstract translation: 一方面，本发明涉及包含活化Atoh1表达的试剂或其药学上可接受的盐，溶剂化物或多晶型物的药物组合物; 以及抑制p27Kip1或其药学上可接受的盐，溶剂合物或多晶型物的表达的试剂，其可用于诱导耳蜗毛细胞的形成; 以及使用该组合物治疗听力障碍或障碍的方法。 一方面，本发明涉及包含β-连环蛋白的药物组合物; 以及激活Atoh1表达的药剂，或其药学上可接受的盐，溶剂化物或多晶型物。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
-
公开(公告)号：US20240002458A1
公开(公告)日：2024-01-04
申请号：US18035502
申请日：2021-11-08
Applicant: St. Jude Children's Research Hospital
Inventor： Taosheng Chen , Wenwei Lin , Yongtao Li
IPC: C07K14/47 , G01N33/58 , G01N33/542
CPC classification number: C07K14/4705 , G01N33/582 , G01N33/542 , C07K2319/60 , G01N2500/00
Abstract: The present disclosure relates to compositions and methods for use in modulating von Hippel-Lindau protein (pVHL) and in identifying pVHL ligands, which can be useful in, for example, treating anti-chronic anemia and anti-chronic ischemia, and also as proteolysis targeting chimeras (PROTACS) to degrade proteins for various therapeutic applications. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
-
公开(公告)号：US11237168B2
公开(公告)日：2022-02-01
申请号：US16453313
申请日：2019-06-26
Applicant: St. Jude Children's Research Hospital
Inventor： J. Paul Taylor , Peiguo Yang , Wenwei Lin , Taosheng Chen
IPC: G01N21/64 , G01N33/573
Abstract: A method of identifying a lead or candidate compound that modulates the activity of GTPase-Activating Protein SH3 Domain-Binding Proteins (G3BP) is provided, which includes determining whether a compound modulates the interaction between the N-terminal Nuclear Transport Factor 2-like (NTF2L) domain of G3BP and FGDF peptide of ubiquitin specific protease 10 (USP10) or non-structural protein 3 (nsP3).
-
公开(公告)号：US10947203B2
公开(公告)日：2021-03-16
申请号：US16679007
申请日：2019-11-08
Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
Inventor： Taosheng Chen , Wenwei Lin , Yueming Wang
IPC: A61K31/4192 , C07D249/06 , A61K9/20 , A61K47/02 , A61K9/00 , A61K47/10 , A61K47/36 , A61P35/00
Abstract: In an aspect, the invention relates to 1,4,5-substituted 1,2,3-triazole and 1,2,4,5-substituted imidazoles having a structure represented by a formula: which are modulators the pregnane X receptor (“PXR”); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of modulating an adverse drug reaction in a mammal using the compounds and pharmaceutical compositions; methods of treatment of a disorder of uncontrolled cellular proliferation, such as a cancer, using the compounds and pharmaceutical compositions; methods of modulating pregnane X receptor activity in a mammal using the compounds and pharmaceutical compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
-
-
-
-
-
-
-
-
-
Search Results
13
records
(took 0.025 seconds)
