公开(公告)号：US20220251167A1

公开(公告)日：2022-08-11

申请号：US17618716

申请日：2020-06-19

Applicant: St. Jude Children's Research Hospital, Inc. ,  UNIVERSITY OF MARYLAND, BALTIMORE

Inventor： Paul THOMAS ,  Jeremy CRAWFORD ,  Allison KIRK ,  Anthony ZAMORA ,  Scott E. STROME

IPC: C07K14/725 ,  A61K39/00 ,  A61P35/00

Abstract: A vector harboring nucleic acids encoding a recombinant T cell receptor having antigenic specificity for a DnaJ heat shock protein family member B1-protein kinase cAMP-activated catalytic subunit alpha (DNAJB1-PRKACA) fusion protein is provided, as are host cells and a method for treating fibrolamellar hepatocellular carcinoma with the vector.

公开(公告)号：US20220326216A1

公开(公告)日：2022-10-13

申请号：US17608079

申请日：2020-04-08

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Benjamin YOUNGBLOOD ,  Jeremy CRAWFORD ,  Yiping FAN ,  Caitlin ZEBLEY ,  Stephen GOTTSCHALK ,  Giedre KRENCIUTE ,  Christopher PETERSEN

IPC: G01N33/50 ,  C07K14/705 ,  A61K35/17

Abstract: The application provides T cell gene expression signatures that can be used to predict T cell therapy outcomes.