公开(公告)号：US12053490B2

公开(公告)日：2024-08-06

申请号：US16759263

申请日：2018-10-25

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Terrence L. Geiger ,  Wenting Zheng ,  Carol E. O'Hear

IPC: A61K35/17 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  C12N15/00 ,  C12N15/62

CPC classification number: A61K35/17 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70578 ,  C07K16/2896 ,  C12N15/00 ,  C12N15/62 ,  C07K16/2803 ,  C07K2317/622 ,  C07K2319/03

Abstract: The application relates to a chimeric receptor that targets CD33 and allows activation of the co-stimulatory pathway without binding the natural ligand. The application also relates to polynucleotides that encode the chimeric receptor, vectors, and host cells comprising the chimeric receptor. The application also relates to methods for preparing host cells comprising a chimeric antigen receptor in order to improve the in vivo persistence of the chimeric antigen receptor host cells.