公开(公告)号：US20240261378A1

公开(公告)日：2024-08-08

申请号：US16321699

申请日：2017-07-31

Applicant: STC UNM

Inventor： Vojo Deretic

IPC: A61K38/53 ,  A61K31/05 ,  A61K31/137 ,  A61K31/155 ,  A61K31/436 ,  A61K31/4375 ,  A61K31/616 ,  A61K31/7016 ,  A61K31/702 ,  A61K38/17 ,  A61K45/06 ,  A61P31/04

CPC classification number: A61K38/53 ,  A61K31/05 ,  A61K31/137 ,  A61K31/155 ,  A61K31/436 ,  A61K31/4375 ,  A61K31/616 ,  A61K31/7016 ,  A61K31/702 ,  A61K38/1732 ,  A61K45/06 ,  A61P31/04

Abstract: Tie present invention relates to compositions and methods of influencing autophagy by modulating TRIM (tripartite motif containing) proteins, especially TRIM 8, TRIM: 10, TRIM 16, TRIM 19 and/or TRIM 51 (preferably TRIM 16} and galectins, especially galectins 3 m order to influence autophagy and treat a number of disease states and/or conditions which are mediated and/or influenced by autophagy, including inflammatory disease states and/or conditions, including a microbial infection such as a Mycobacterium infection, among numerous others, an inflammatory disorder, a lysosomal, storage disorder, an immune disorder, a neurodegenerative disorder and a cancer.