公开(公告)号：US10548994B1

公开(公告)日：2020-02-04

申请号：US14196343

申请日：2014-03-04

Applicant: STC.UNM

Inventor： Erin Damita Milligan ,  Jeffrey P. Norenberg

IPC: A61K31/4166 ,  A61K51/04 ,  A61K31/4174 ,  A61K38/18 ,  A61K38/20 ,  A61K38/34

Abstract: In one embodiment, the invention provides a method of treating a subject suffering from chronic neuropathic pain and/or allodynia by administering a therapeutically-effective amount of at least one LFA1 antagonist to the subject. In a preferred embodiment, the invention provides a method of treating a subject suffering from chronic neuropathic pain and/or allodynia, the method comprising administering intrathecally to the subject a therapeutically-effective amount of microparticles comprising PLGA-encapsulated pDNA-IL-10, optionally in combination with a therapeutically-effective amount of intrathecally-administered CpG oligodeoxynucleotide (CpG ODN) and/or at least one LFA1 antagonist.