公开(公告)号：US20190202922A1

公开(公告)日：2019-07-04

申请号：US16333898

申请日：2017-09-21

Applicant: STC.UNM ,  LOS ALAMOS NATIONAL SECURITY, LLC

Inventor： RENATA PASQUALINI ,  WADIH ARAP ,  FERNANDA IAMASSAKA STAQUICINI ,  FORTUNATO FERRARA ,  ANDREW R.M. BRADBURY

IPC: C07K16/28 ,  A61K47/68 ,  A61K38/07 ,  A61K39/395 ,  G01N33/574 ,  C07K16/18 ,  C12N15/10

CPC classification number: C07K16/2866 ,  A61K38/07 ,  A61K39/3955 ,  A61K47/6803 ,  A61K47/6817 ,  A61K47/6843 ,  A61K47/6849 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/77 ,  C12N15/1037 ,  G01N33/57423

Abstract: Isolated or recombinant Eph A5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vim methodologies is also provided.