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1.发明申请PROTOCELLS AND THEIR USE FOR TARGETED DELIVERY OF MULTICOMPONENT CARGOS TO CANCER CELLS 审中-公开方案及其用于向癌细胞定向递送多种载体的方法公开(公告)号：US20150164798A1
公开(公告)日：2015-06-18
申请号：US14627739
申请日：2015-02-20
申请人： STC.UNM , SANDIA CORPORATION
发明人： C. Jeffrey Brinker , Carlee Erin Ashley , Xingmao Jiang , Juewen Liu , David S. Peabody , Walker Richard Wharton , Eric Carnes , Bryce Chackerian , Cheryl L. Willman
IPC分类号： A61K9/127 , A61K31/704
CPC分类号： A61K9/127 , A61K9/1277 , A61K9/5115 , A61K9/5123 , A61K31/513 , A61K31/575 , A61K31/704 , A61K33/24 , A61K49/005
摘要： Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to the porous particle core to form a protocell. The lipid bilayer can be modified with targeting ligands or other ligands to achieve targeted delivery of cargo components that are loaded within the protocell to a target cell, e.g., a type of cancer. Shielding materials can be conjugated to the surface of the lipid bilayer to reduce undesired non-specific binding.
摘要翻译： 各种实施方案提供用于合成原细胞以用于向癌细胞靶向递送货物组分的材料和方法。 在一个实施方案中，脂质双层可以与多孔颗粒核心融合以形成原细胞。 脂质双层可以用靶向配体或其他配体进行修饰，以实现载体在原细胞内的货物组分的靶向递送到靶细胞，例如一种类型的癌症。 屏蔽材料可以结合到脂质双层的表面以减少不期望的非特异性结合。
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公开(公告)号：US09480653B2
公开(公告)日：2016-11-01
申请号：US14627739
申请日：2015-02-20
申请人： STC.UNM , SANDIA CORPORATION
发明人： C. Jeffrey Brinker , Carlee Erin Ashley , Xingmao Jiang , Juewen Liu , David S. Peabody , Walker Richard Wharton , Eric Carnes , Bryce Chackerian , Cheryl L. Willman
IPC分类号： A61K9/56 , A61K9/127 , A61K9/51 , A61K49/00 , A61K31/575 , A61K31/513 , A61K33/24 , A61K31/704
CPC分类号： A61K9/127 , A61K9/1277 , A61K9/5115 , A61K9/5123 , A61K31/513 , A61K31/575 , A61K31/704 , A61K33/24 , A61K49/005
摘要： Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to the porous particle core to form a protocell. The lipid bilayer can be modified with targeting ligands or other ligands to achieve targeted delivery of cargo components that are loaded within the protocell to a target cell, e.g., a type of cancer. Shielding materials can be conjugated to the surface of the lipid bilayer to reduce undesired non-specific binding.
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3.发明申请公开(公告)号：US20150320681A1
公开(公告)日：2015-11-12
申请号：US14797487
申请日：2015-07-13
申请人： STC.UNM , SANDIA CORPORATION
发明人： C. Jeffrey Brinker , Carlee Erin Ashley , Xingmao Jiang , Juewen Liu , David S. Peabody , Walker Richard Wharton , Eric Carnes , Bryce Chackerian , Cheryl L. Willman
IPC分类号： A61K9/127 , A61K33/24 , A61K31/704 , A61K31/513 , A61K49/00 , A61K31/575
CPC分类号： A61K9/127 , A61K9/1277 , A61K9/5115 , A61K9/5123 , A61K31/513 , A61K31/575 , A61K31/704 , A61K33/24 , A61K49/005
摘要： Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to the porous particle core to form a protocell. The lipid bilayer can be modified with targeting ligands or other ligands to achieve targeted delivery of cargo components that are loaded within the protocell to a target cell, e.g., a type of cancer. Shielding materials can be conjugated to the surface of the lipid bilayer to reduce undesired non-specific binding.
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公开(公告)号：US20180169009A1
公开(公告)日：2018-06-21
申请号：US15577572
申请日：2016-06-01
申请人： Patrick JOHNSON , C. Jeffrey BRINKER , Eric CARNES , Graham TIMMINS , Pavan MUTTIL , STC.UNM
CPC分类号： A61K9/0073 , A61K9/12 , A61K9/1271 , A61K9/1617 , A61K47/543 , C08L23/22
摘要： This disclosure describes compositions, vaccine, and methods that involve a biocomposite material Generally, the biocomposite material includes a cell and a lipid-silica matrix at least partially encapsulating the cell. In some cases, the cell can be viable but not culturable (VBNC). In some cases, the lipid-silica matrix includes a dried sol and/or possesses ordered nanostructure.
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