公开(公告)号：US20180105430A1

公开(公告)日：2018-04-19

申请号：US15557368

申请日：2016-03-11

Applicant: STC.UNM ,  SANDIA CORPORATION

Inventor： Eric C. Carnes ,  C. jeffrey Brinker ,  Darren Dunphy ,  Trevin Heisey

IPC: C01B33/18

CPC classification number: C01B33/18 ,  A61K9/5115 ,  A61K9/5123 ,  A61K33/00 ,  B82Y40/00 ,  C01B37/02 ,  C01P2004/64 ,  C01P2006/14 ,  C01P2006/17

Abstract: The present invention relates to the discovery that mesoporous silica nanoparticles may be modified in pore size from the natural mesophase by generating mesoporous materials in binary, ternary or multiphase surfactant systems to produce biphasic, triphasic or multiphase mesoporous structures. Thus, the present invention relates to methods of producing biphase, triphasic and multiphase mesoporous structures with finely tuned mesopore size and protocells which are produced therefrom and mesoporous silica nanoparticles obtained therefrom. The resulting mesoporous nanostructures may be used to create protocells having unique cargo loading and release characteristics. Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.