公开(公告)号：US12201652B2

公开(公告)日：2025-01-21

申请号：US16098404

申请日：2017-05-03

Applicant: STEMCELL TECHNOLOGIES CANADA INC.

Inventor： Jonathan B. Gilbert ,  Bu Wang ,  Scott Loughhead ,  Howard Bernstein ,  Armon R. Sharei ,  Finola Moore

IPC: A61K35/18 ,  A61K35/19 ,  A61K39/00 ,  A61K39/385 ,  A61P37/06 ,  C12M1/12 ,  C12M3/06 ,  C12N5/078 ,  C12N15/85 ,  C12N15/87

Abstract: The present invention provides methods for inducing tolerance and/or suppressing an immune response to an antigen by passing a cell suspension containing an anucleate cell through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that an antigen and/or tolerogenic factor enters the cell. In some embodiments, the anucleate cell is delivered to an individual and the antigen is delivered to and processed in a tolerogenic environment to induce tolerance and/or suppress an immune response to the antigen.