公开(公告)号：US12102668B2

公开(公告)日：2024-10-01

申请号：US16298112

申请日：2019-03-11

申请人： RegenLab USA LLC

发明人： Antoine Turzi

IPC分类号： A61K36/16 ,  A61K8/98 ,  A61K31/728 ,  A61K35/14 ,  A61K35/15 ,  A61K35/16 ,  A61K35/17 ,  A61K35/18 ,  A61K35/19 ,  A61K38/36 ,  A61K38/48 ,  A61L26/00 ,  A61M1/02 ,  A61M5/19 ,  A61Q19/08

CPC分类号： A61K38/4833 ,  A61K8/981 ,  A61K8/983 ,  A61K31/728 ,  A61K35/14 ,  A61K35/15 ,  A61K35/16 ,  A61K35/17 ,  A61K35/18 ,  A61K35/19 ,  A61K38/363 ,  A61L26/0057 ,  A61L26/0066 ,  A61M1/0209 ,  A61M1/029 ,  A61M5/19 ,  A61Q19/08 ,  C12Y304/21005 ,  A61L2300/30 ,  A61L2300/412 ,  A61M2202/0425 ,  A61M2202/0427 ,  A61K35/16 ,  A61K2300/00 ,  A61K35/14 ,  A61K2300/00 ,  A61K35/19 ,  A61K2300/00 ,  A61K35/17 ,  A61K2300/00 ,  A61K35/15 ,  A61K2300/00 ,  A61K38/363 ,  A61K2300/00 ,  A61K35/18 ,  A61K2300/00 ,  A61K31/728 ,  A61K2300/00

摘要： The present invention is related to the field of tissue regeneration. It concerns more particularly new processes, tubes and devices for thrombin, platelet concentrate and wound healant preparations, alone or in combination with cell extracts, cell compositions and uses thereof.

公开(公告)号：US12097221B2

公开(公告)日：2024-09-24

申请号：US17428590

申请日：2020-02-07

申请人： REGROW BIOSCIENCES PRIVATE LIMITED

发明人： Satyen Sanghavi ,  Vinayak Kedage

IPC分类号： A61K35/19 ,  A61K35/32 ,  A61K35/51 ,  C12N5/0775 ,  C12N5/078

CPC分类号： A61K35/19 ,  A61K35/32 ,  A61K35/51 ,  C12N5/0644 ,  C12N5/0665 ,  C12N2523/00 ,  C12N2525/00

摘要： The present disclosure discloses a method for preparing a lysate, from a combination of umbilical cord blood (UCB) and maternal blood (MB) derived platelets by obtaining platelet-rich plasma via sedimentation processes and then mixing platelet-rich plasmas so obtained. The present disclosure further discloses a combination of umbilical cord blood and maternal blood platelet lysate (UCB+MB PL), and the PL so obtained shows greater efficacy as cell and tissue culture media supplement over and above its individual components, umbilical cord blood platelet lysate (UCB PL) and maternal blood platelet lysate (MB PL) and especially over foetal bovine serum (FBS). Moreover, the method of the present disclosure provides an economic, environment friendly, ethical and efficacious method to reach a cell and tissue culture supplement with far-reaching therapeutic applications.

公开(公告)号：US12090234B2

公开(公告)日：2024-09-17

申请号：US18100821

申请日：2023-01-24

申请人： STRM.bio Incorporated

发明人： Jonathan Thon

IPC分类号： A61K9/50 ,  A61K9/127 ,  A61K35/19 ,  A61K48/00 ,  C12N5/078 ,  C12N13/00

CPC分类号： A61K9/5068 ,  A61K9/127 ,  A61K35/19 ,  A61K48/0033 ,  C12N5/0644 ,  C12N13/00 ,  C12N2506/03 ,  C12N2506/11

摘要： Disclosed herein are compositions and methods related to megakaryocyte-derived extracellular vesicles derived from human pluripotent stem cells, where the megakaryocyte-derived extracellular vesicles may be utilized for drug delivery and treating various diseases.

公开(公告)号：US12011463B2

公开(公告)日：2024-06-18

申请号：US16933492

申请日：2020-07-20

申请人： Reapplix ApS

发明人： Rasmus Lundquist ,  Niels Erik Holm

IPC分类号： A61K35/19 ,  A61K35/15 ,  A61K35/33 ,  A61K38/15 ,  A61K38/17 ,  A61K38/36 ,  A61L24/10 ,  B04B5/04 ,  C12N5/078 ,  C12N5/0787 ,  G01N33/49 ,  A61L26/00 ,  A61M1/02

CPC分类号： A61K35/19 ,  A61K35/15 ,  A61K35/33 ,  A61K38/15 ,  A61K38/17 ,  A61K38/36 ,  A61K38/363 ,  A61L24/106 ,  B04B5/04 ,  C12N5/0642 ,  C12N5/0644 ,  G01N33/49 ,  A61L26/0042 ,  A61M1/029 ,  B04B2005/0485 ,  C12N2501/905 ,  G01N33/491 ,  A61K38/363 ,  A61K2300/00 ,  A61K38/15 ,  A61K2300/00 ,  A61K38/17 ,  A61K2300/00 ,  A61K35/19 ,  A61K2300/00 ,  A61K35/15 ,  A61K2300/00

摘要： A blood product (10), a method for preparing the blood product, a blood product obtainable by the method and a blood product preparing container means. The blood product comprises components from whole blood, especially fibrin, thrombocytes and leukocytes. The blood product (10) comprises a first layer (21), a second layer (22) and a third layer (23). The second layer (22) is adjacent to the first layer (21) and the third layer (23). The first layer (21) defines a first outer surface (24) of the blood product (10) and the third layer (23) defining a second outer surface (25) of the blood product (10). The first layer (21) comprises a majority of fibrin, the second layer (22) comprises a majority of thrombocytes and the third layer (23) comprises a majority of leukocytes.

公开(公告)号：US20240139252A1

公开(公告)日：2024-05-02

申请号：US18406008

申请日：2024-01-05

申请人： Cellphire, Inc.

发明人： Keith Andrew MOSKOWITZ ,  Shan XU ,  William Matthew DICKERSON ,  Amber Nicole LEE ,  Braden Carl ISHLER ,  Daniel Allen SHEIK

IPC分类号： A61K35/19 ,  A61K9/19 ,  A61K9/50 ,  A61K31/195 ,  A61K31/197 ,  A61K38/36 ,  A61K38/57 ,  A61P7/04 ,  C12N5/078

CPC分类号： A61K35/19 ,  A61K9/19 ,  A61K9/5068 ,  A61K31/195 ,  A61K31/197 ,  A61K38/363 ,  A61K38/57 ,  A61P7/04 ,  C12N5/0644

摘要： Provided herein are methods and compositions for treating von Willebrand disease with platelets, platelet derivatives, and/or thrombosomes.

公开(公告)号：US11965179B1

公开(公告)日：2024-04-23

申请号：US17353388

申请日：2021-06-21

申请人： Fariborz Izadyar

发明人： Fariborz Izadyar

IPC分类号： C12N5/078 ,  A61K9/00 ,  A61K35/19 ,  C12N11/04 ,  C12N13/00

CPC分类号： C12N5/0644 ,  A61K9/0019 ,  A61K9/0095 ,  A61K35/19 ,  C12N11/04 ,  C12N13/00 ,  C12N2509/00 ,  C12N2529/00

摘要： A method of creating a pooled platelet lysate product may include obtaining whole blood from a source; separating platelets from the whole blood using a pressurized rotating microfluidic filtration system; creating platelet rich plasma (PRP) by concentrating the platelets in plasma and removing red blood cells and white blood cells using centrifugation; centrifuging the PRP, removing the plasma, and re-suspending the PRP in the lactated ringers solution (LRS) to create concentrated PRP (C-PRP); laser activating the C-PRP to create an activated C-PRP product; freezing and thawing the activated C-PRP product at least 3 times, wherein vortexing and sonication are performed after each thaw; and reconstituting the activated C-PRP in a saline to create a platelet lysate product with a known potency.

公开(公告)号：US11951134B2

公开(公告)日：2024-04-09

申请号：US17039418

申请日：2020-09-30

申请人： North Carolina State University ,  The Trustees of the University of Pennsylvania

发明人： Jessica M. Gilbertie ,  Lauren V. Schnabel ,  Thomas P. Schaer

IPC分类号： A61K35/19 ,  A61K35/15 ,  A61K35/18 ,  A61P17/02

CPC分类号： A61K35/19 ,  A61K35/15 ,  A61K35/18 ,  A61P17/02

摘要： An acellular, anion-depleted platelet-derived peptide-rich composition comprising proteins, polypeptides and peptides

公开(公告)号：US11903971B2

公开(公告)日：2024-02-20

申请号：US17166490

申请日：2021-02-03

申请人： Cellphire, Inc.

发明人： Keith Andrew Moskowitz ,  Shan Xu ,  William Matthew Dickerson ,  Amber Nicole Lee ,  Braden Carl Ishler ,  Daniel Allen Sheik

IPC分类号： A61K35/19 ,  A61K9/19 ,  A61P7/04 ,  A61K31/195 ,  A61K31/197 ,  A61K38/36 ,  A61K38/57 ,  A61K9/50 ,  C12N5/078

CPC分类号： A61K35/19 ,  A61K9/19 ,  A61K9/5068 ,  A61K31/195 ,  A61K31/197 ,  A61K38/363 ,  A61K38/57 ,  A61P7/04 ,  C12N5/0644

摘要： Provided herein are methods and compositions for treating von Willebrand disease with platelets, platelet derivatives, and/or thrombosomes.

公开(公告)号：US20230414663A1

公开(公告)日：2023-12-28

申请号：US18248825

申请日：2021-10-15

申请人： BIOMEDICAL RESEARCH S.R.L.

发明人： Giuseppa ZARBO

IPC分类号： A61K35/19 ,  A61K35/20 ,  A61K9/00 ,  A61K47/36 ,  A61K47/18 ,  A61P27/04 ,  A61P17/02

CPC分类号： A61K35/19 ,  A61K35/20 ,  A61K9/0014 ,  A61P17/02 ,  A61K9/0019 ,  A61K47/183 ,  A61P27/04 ,  A61K47/36

摘要： Topical or injection compositions for use in the treatment of conditions requiring tissue repair and regeneration in humans and animals are provided. The topical or injection compositions include autologous platelet concentrates and a colostrum isolate mixture of biological factors.

公开(公告)号：US20230383257A1

公开(公告)日：2023-11-30

申请号：US18248193

申请日：2021-10-15

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Elizabeth SHPALL ,  Katy REZVANI ,  Bijender KUMAR ,  Mayela MENDT ,  Vahid AFSHAR-KHARGHAN ,  Rafet BASAR

IPC分类号： C12N5/078 ,  A61K35/19

CPC分类号： C12N5/0644 ,  A61K35/19 ,  C12N2506/1369 ,  C12N2502/11 ,  C12N2501/727 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/2306 ,  C12N2501/724

摘要： Embodiments of the disclosure include systems, methods, and compositions for producing megakaryocytes and platelets for recipient individuals in need thereof. The megakaryocytes and platelets are produced following co-culture of MSCs and CD34+ cells in media comprising stem cell factor, thrombopoietin, and IL-6, and wherein at least the CD34+ cells have a knock-in of HLA-E at the beta-2-microglobulin genomic locus, in specific embodiments. In some cases, ROCK inhibitors are utilized.