公开(公告)号：US20230212241A1

公开(公告)日：2023-07-06

申请号：US18069421

申请日：2022-12-21

Applicant: STEMRIM INC. ,  OSAKA UNIVERSITY

Inventor： KATSUTO TAMAI ,  TAKEHIKO YAMAZAKI ,  TSUTOMU KANEZAKI ,  SHIGERU SAKURAI ,  YUKIKO NOGUCHI ,  MAYUMI ENDO ,  NATSUMI HAMABUCHI ,  KANA NAITO

IPC: C07K14/47 ,  A61K38/17 ,  C12N15/85

CPC classification number: C07K14/4705 ,  A61K38/1709 ,  C12N15/85 ,  C07K2319/21 ,  C07K2319/50 ,  C12N2510/00

Abstract: (Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFRα-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body.
(Means for solution) Multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a PDGFRα-positive bone marrow mesenchymal stem cell line (MSC-1). Further, the present inventors confirmed that the identified peptides also have migration-promoting activity on skin fibroblasts, which are PDGFRα-positive cells.

公开(公告)号：US20200369736A1

公开(公告)日：2020-11-26

申请号：US16713202

申请日：2019-12-13

Applicant: STEMRIM INC. ,  OSAKA UNIVERSITY

Inventor： KATSUTO TAMAI ,  TAKEHIKO YAMAZAKI ,  TSUTOMU KANEZAKI ,  SHIGERU SAKURAI ,  YUKIKO NOGUCHI ,  MAYUMI ENDO ,  NATSUMI HAMABUCHI ,  KANA NAITO

IPC: C07K14/47

Abstract: (Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFRα-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body.(Means for solution) Multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a PDGFRα-positive bone marrow mesenchymal stem cell line (MSC-1). Further, the present inventors confirmed that the identified peptides also have migration-promoting activity on skin fibroblasts, which are PDGFRα-positive cells.

公开(公告)号：US20180072785A1

公开(公告)日：2018-03-15

申请号：US15691017

申请日：2017-08-30

Applicant: GENOMIX CO., LTD. ,  OSAKA UNIVERSITY

Inventor： KATSUTO TAMAI ,  TAKEHIKO YAMAZAKI ,  TSUTOMU KANEZAKI ,  SHIGERU SAKURAI ,  YUKIKO NOGUCHI ,  MAYUMI ENDO ,  NATSUMI HAMABUCHI ,  KANA NAITO

IPC: C07K14/47

Abstract: (Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFRα-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body.(Means for solution) Multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a PDGFRα-positive bone marrow mesenchymal stem cell line (MSC-1). Further, the present inventors confirmed that the identified peptides also have migration-promoting activity on skin fibroblasts, which are PDGFRα-positive cells.