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公开(公告)号:US20100330078A1
公开(公告)日:2010-12-30
申请号:US12365638
申请日:2009-02-04
申请人: STEVEN L. BENDER , GERALD F. CASPERSON , DANA D. HU-LOWE , XIN JIANG , GANG LI , MICHAEL A. NORTH , JIANYING WANG , GRANT WICKMAN , PETER BRAMS , HAICHUN HUANG , BRIGITTE DEVAUX , HAIBIN CHEN , DAWN M. TANAMACHI , KRISTOPHER TOY , LAN YANG , TIM W. SPROUL , MARK YAMANAKA
发明人: STEVEN L. BENDER , GERALD F. CASPERSON , DANA D. HU-LOWE , XIN JIANG , GANG LI , MICHAEL A. NORTH , JIANYING WANG , GRANT WICKMAN , PETER BRAMS , HAICHUN HUANG , BRIGITTE DEVAUX , HAIBIN CHEN , DAWN M. TANAMACHI , KRISTOPHER TOY , LAN YANG , TIM W. SPROUL , MARK YAMANAKA
IPC分类号: A61K39/395 , C07K16/28 , C07K16/00 , A61P35/00
CPC分类号: C07K16/2842 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要: The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-α5β1 antibodies or antigen binding portions thereof described herein.
摘要翻译: 本公开提供以高亲和力特异性结合整联蛋白α5和bgr1的分离的单克隆抗体,特别是人单克隆抗体或其抗原结合部分。 还提供了编码本公开的抗体的核酸分子,表达载体,宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物,双特异性分子和包含抗体或其抗原结合部分的药物组合物。 本公开还提供了使用本文所述的抗α5和bgr1抗体或其抗原结合部分治疗各种癌症的方法。