公开(公告)号：US20230390371A1

公开(公告)日：2023-12-07

申请号：US18032183

申请日：2021-10-18

申请人： STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS

发明人： Reuven AGAMI ,  Abhijeet PATASKAR ,  Julien CHAMPAGNE ,  Yardena SAMUELS ,  Osnat BARTOK

IPC分类号： A61K39/00 ,  C12P21/02 ,  C07K14/435

CPC分类号： A61K39/00119 ,  C12P21/02 ,  C07K14/435 ,  A61K2039/70 ,  A61K2039/53 ,  A61K2039/876 ,  A61K2039/55522

摘要： The invention relates to methods of producing at least one out-of-frame peptide of 5-40 amino acid residues by a cell, and to methods of identifying said at least one out-of-frame peptide. The invention further relates to the identified out-of-frame peptides, and epitopes and polyepitopes encompassing at least one of said out-of-frame peptides, and to a nucleic acid molecule encoding at least one of said out-of-frame peptides. The invention further relates to methods of inducing an immune response against at least one out-of-frame peptide, method of treating an individual suffering from a tumor, comprising providing said individual with at least one out-of-frame peptide, and to a pharmaceutical composition, comprising at least one out-of-frame peptide. The invention additionally relates to a kit for detecting expression of at least one out-of-frame peptide, and to methods of typing an individual for presence or absence of a cell that expresses at least one out-of-frame peptide.