公开(公告)号：US3882243A

公开(公告)日：1975-05-06

申请号：US28194172

申请日：1972-08-18

Applicant: SUMITOMO CHEMICAL CO

Inventor： MAEDA TADAO ,  KIYOTAKI TOMOAKI ,  KATSUHARA YASUO ,  MITSUNAGA TAKAYOSHI ,  IWADE MITSUO

IPC: C07C231/22 ,  A61K47/26 ,  C07C67/00 ,  C07C231/00 ,  C07C233/18 ,  A61K21/00

CPC classification number: A61K47/26 ,  Y10S514/97 ,  Y10S514/975

Abstract: A process for preparing an aqueous suspension of stable nonBeta -type crystals of a chloramphenicol high fatty acid esters by suspending non- Beta -type crystals of a chloramphenicol higher fatty acid ester with a sucrose fatty acid ester in water. Also provided herein is a stable pharmaceutical composition in the form of the aqueous suspension of the aforementioned components.

Abstract translation: 通过将氯霉素高级脂肪酸酯的非β-型晶体与蔗糖脂肪酸酯悬浮在水中来制备氯霉素高脂肪酸酯的稳定非β-型晶体的水性悬浮液的方法。 本文还提供了上述组分的水性悬浮液形式的稳定的药物组合物。

公开(公告)号：US3881020A

公开(公告)日：1975-04-29

申请号：US20915071

申请日：1971-12-17

Applicant: SUMITOMO CHEMICAL CO

Inventor： NAKAMURA TOSHIO ,  MAEDA TADAO ,  KIYOTAKI TOMOAKI ,  KATSUHARA YASUO ,  SAKAMOTO YOSHIO ,  IWADE MITSUO

IPC: C07C231/22 ,  A61K9/00 ,  A61K9/14 ,  C07C67/00 ,  C07C231/00 ,  C07C233/18 ,  A61K27/00

CPC classification number: A61K9/0095 ,  A61K9/14

Abstract: An aqueous suspension of chloramphenicol palmitate is prepared by melting chloramphenicol palmitate previously alone, mixing the melt with a hot aqueous solution containing one or more dispersing agents, cooling the dispersion, and then warming the same to prepare a bitterless aqueous suspension containing extremely fine and uniform alpha-type crystals of chloramphenicol palmitate having a high bioactivity.

Abstract translation: 通过单独将氯霉素棕榈酸酯熔化，将熔体与含有一种或多种分散剂的热水溶液混合，冷却分散体，然后加热，制备无水水性悬浮液，制备含有极细和均匀的无水水性悬浮液 具有高生物活性的氯霉素棕榈酸酯的α型晶体。