公开(公告)号：US20210128506A1

公开(公告)日：2021-05-06

申请号：US16640060

申请日：2018-06-12

Applicant: SUN YAT-SEN UNIVERSITY

Inventor： Hui LI ,  Bo PENG ,  Xuanxian PENG

IPC: A61K31/194 ,  A61P31/04 ,  A61K31/43

Abstract: The present invention belongs to the technical field of medicine, and specifically relates to use of succinic acid in increasing sensitivity of bacteria to antibiotics. The present invention found that the succinic acid can increase proton motive force of bacteria, thereby increasing the number of antibiotics entering the bacteria, and eventually killing the bacteria. Therefore, the succinic acid can increase the sensitivity of bacteria to antibiotics, thereby overcoming the problem of bacterial drug resistance. Combining succinic acid with antibiotics can significantly improve the bactericidal effect of the antibiotics, which has better effects and higher safety and operability compared with only using antibiotics as antibacterial drugs at present.

公开(公告)号：US20150297547A1

公开(公告)日：2015-10-22

申请号：US14649667

申请日：2012-12-04

Applicant: SUN YAT-SEN UNIVERSITY

Inventor： Xuanxian PENG ,  Hui LI ,  Xianliang ZHAO

IPC: A61K31/198 ,  A61K31/7004 ,  A61K31/43

CPC classification number: A61K31/198 ,  A61K31/43 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/546 ,  A61K31/7004 ,  A61K31/7036 ,  A61K31/7048 ,  A61K31/7056 ,  Y02A50/473 ,  A61K2300/00

Abstract: Disclosed is a new function of a small molecule metabolite glutamine. The small molecule can improve sensitivity of bacteria including antibiotic-resistant bacteria to antibiotics. Also disclosed is an application of glutamine in combination with glucose in improving sensitivity of bacteria to antibiotics.

Abstract translation: 公开了一种小分子代谢物谷氨酰胺的新功能。 小分子可以提高抗生素抗性细菌对抗生素的敏感性。 还公开了谷氨酰胺与葡萄糖组合的应用，以提高细菌对抗生素的敏感性。

公开(公告)号：US20220409563A1

公开(公告)日：2022-12-29

申请号：US17787592

申请日：2021-07-20

Applicant: SUN YAT-SEN UNIVERSITY

Inventor： Hui LI ,  Bo PENG ,  Xuanxian PENG ,  Shishi LAI

IPC: A61K31/198 ,  A61K31/401 ,  A61K31/405 ,  A61K31/407 ,  A61K31/4709 ,  A61K31/4172 ,  A61K31/43 ,  A61K31/546 ,  A61K31/7036 ,  A61P31/04

Abstract: The invention belongs to the technical field of biomedicament, and more specifically relates to an application of compound amino acids in preparation of a medicament for improving sensitivity of bacteria to antibiotics. Experiments have shown that a combination of compound amino acids and antibiotics can improve the sensitivity of bacteria to antibiotics, promote an entry of antibiotics into bacterial cells, significantly increase an intracellular antibiotic content, and improve a bactericidal effect of antibiotics, thereby reducing a survival rate of bacteria, and treating diseases caused by bacterial infection.

公开(公告)号：US20250041254A1

公开(公告)日：2025-02-06

申请号：US18717426

申请日：2022-12-15

Applicant: SUN YAT-SEN UNIVERSITY

Inventor： Hui LI ,  Bo PENG ,  Xuanxian PENG ,  Sufang KUANG

IPC: A61K31/19 ,  A61K31/7048 ,  A61P31/04

Abstract: The present invention belongs to the technical field of biological medicine, and specifically relates to use of sodium formate in preparation of an anti-infective drug. The present invention has found through research that sodium formate can significantly increase the sensitivity of a bacterium to an antibiotic, so that the antibiotic that is originally ineffective or inefficient against a pathogenic bacterium becomes effective or efficient, thereby killing the bacterium and achieving an anti-infective effect. Sodium formate and an antibiotic are further prepared into an anti-infective composition, so that on the one hand, a significant anti-infective effect can be achieved under the condition of a low-concentration antibiotic, and on the other hand, the decreased use amount of the antibiotic can also significantly reduce the likelihood of a bacterium developing drug resistance; and sodium formate has been widely used in food and medicine with high safety.