公开(公告)号：US20160317510A1

公开(公告)日：2016-11-03

申请号：US14958103

申请日：2015-12-03

Applicant: Sunesis Pharmaceuticals, Inc.

Inventor： Jeffrey A. SILVERMAN

IPC: A61K31/4375 ,  A61K31/7068 ,  A61K9/00 ,  A61K45/06 ,  A61K33/24 ,  A61K31/555

CPC classification number: A61K31/4375 ,  A61K9/0019 ,  A61K31/282 ,  A61K31/555 ,  A61K31/7068 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

Abstract: Methods of treating, preventing or managing cancers are disclosed. The methods encompass the administration of SNS-595 in combination with a second active agent. In certain embodiments, the method of treatment comprise administering SNS-595 in combination with cisplatin, carboplatin, gemcitabine or a combination thereof.

Abstract translation: 公开了治疗，预防或治疗癌症的方法。 所述方法包括与第二活性剂组合施用SNS-595。 在某些实施方案中，治疗方法包括与顺铂，卡铂，吉西他滨或其组合组合施用SNS-595。

公开(公告)号：US20150150858A1

公开(公告)日：2015-06-04

申请号：US14320414

申请日：2014-06-30

Applicant: SUNESIS PHARMACEUTICALS, INC.

Inventor： Daniel C. ADELMAN ,  Marc J. EVANCHIK ,  Anantha SUDHAKAR ,  Jeffrey William JACOBS ,  Jeffrey A. SILVERMAN

IPC: A61K31/4375

CPC classification number: C07D471/04 ,  A61K31/4375 ,  A61K31/4745 ,  C07D417/14 ,  A61K2300/00

Abstract: Compounds and compositions for treating, preventing or managing cancer are disclosed. The compositions provided herein comprise SNS-595 and N-desmethyl-SNS-595. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment using the compounds and compositions.

Abstract translation: 公开了用于治疗，预防或控制癌症的化合物和组合物。 本文提供的组合物包含SNS-595和N-去甲基-SNS-595。 还提供了包含化合物的药物组合物和使用该化合物和组合物的治疗方法。