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    Triple reuptake inhibitors and methods of their use
    1.
    发明授权
    Triple reuptake inhibitors and methods of their use 有权
    三重再摄取抑制剂及其使用方法

    公开(公告)号：US09133117B2

    公开(公告)日：2015-09-15

    申请号：US14062626

    申请日：2013-10-24

    Applicant: SUNOVION PHARMACEUTICALS INC.

    Inventor： Liming Shao ,  Fengjiang Wang ,  Scott C. Malcolm ,  Michael C. Hewitt

    IPC: C07D209/44 ,  C07D205/00 ,  C07D217/00 ,  C07D217/10 ,  C07D209/52 ,  C07D209/08

    CPC classification number: C07D209/44 ,  A61K31/4035 ,  C07D209/08 ,  C07D209/52

    Abstract: Provided herein are bicyclic compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders. Compounds provided herein inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations containing the compounds are also provided.

    Abstract translation: 本文提供的是双环化合物及其合成方法。 本文提供的化合物可用于治疗，预防和/或管理各种神经障碍。 本文提供的化合物抑制内源性单胺如多巴胺，5-羟色胺和去甲肾上腺素的再摄取（例如，从突触腭裂）并调节一种或多种单胺转运蛋白。 还提供了含有这些化合物的药物制剂。

    TRIPLE REUPTAKE INHIBITORS AND METHODS OF THEIR USE
    3.
    发明申请
    TRIPLE REUPTAKE INHIBITORS AND METHODS OF THEIR USE 有权
    三倍体复制抑制剂及其使用方法

    公开(公告)号：US20160221947A1

    公开(公告)日：2016-08-04

    申请号：US14850338

    申请日：2015-09-10

    Applicant: Sunovion Pharmaceuticals Inc.

    Inventor： Liming Shao ,  Fengjiang Wang ,  Scott C. Malcolm ,  Michael C. Hewitt

    IPC: C07D209/44 ,  A61K31/4035

    CPC classification number: C07D209/44 ,  A61K31/4035 ,  C07D209/08 ,  C07D209/52

    Abstract: Provided herein are bicyclic compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders. Compounds provided herein inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations containing the compounds are also provided.

    Abstract translation: 本文提供的是双环化合物及其合成方法。 本文提供的化合物可用于治疗，预防和/或管理各种神经障碍。 本文提供的化合物抑制内源性单胺如多巴胺，5-羟色胺和去甲肾上腺素的再摄取（例如，从突触腭裂）并调节一种或多种单胺转运蛋白。 还提供了含有这些化合物的药物制剂。

    TRIPLE REUPTAKE INHIBITORS AND METHODS OF THEIR USE
    4.
    发明申请
    TRIPLE REUPTAKE INHIBITORS AND METHODS OF THEIR USE 审中-公开
    三倍体复制抑制剂及其使用方法

    公开(公告)号：US20140107175A1

    公开(公告)日：2014-04-17

    申请号：US14062626

    申请日：2013-10-24

    Applicant: SUNOVION PHARMACEUTICALS INC.

    Inventor： Liming SHAO ,  Fengjiang Wang ,  Scott C. Malcolm ,  Michael C. Hewitt

    IPC: C07D209/52

    CPC classification number: C07D209/44 ,  A61K31/4035 ,  C07D209/08 ,  C07D209/52

    Abstract: Provided herein are bicyclic compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders. Compounds provided herein inhibit re-uptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations containing the compounds are also provided.

    Abstract translation: 本文提供的是双环化合物及其合成方法。 本文提供的化合物可用于治疗，预防和/或管理各种神经障碍。 本文提供的化合物抑制内源性单胺如多巴胺，5-羟色胺和去甲肾上腺素（例如，从突触裂缝）的再摄取并调节一种或多种单胺转运蛋白。 还提供了含有这些化合物的药物制剂。

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