公开(公告)号：US20160355501A1

公开(公告)日：2016-12-08

申请号：US15034546

申请日：2014-12-19

Applicant: SUNSHINE LAKE PHARMA CO., LTD.

Inventor： Jiancun Zhang ,  Xiaojun WANG ,  Yingjun ZHANG ,  Runfeng LIN ,  Yi YU ,  Liang CHEN ,  Jihua LIN

IPC: C07D401/10 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14

CPC classification number: C07D401/10 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention relates to the field of medicine, provided herein are novel nitrogenous heterocyclic compounds, their preparation methods and their uses as drugs, especially for treatment and prevention of tissue fibrosis. Also provided herein are pharmaceutically acceptable compositions comprising the nitrogenous heterocyclic compounds and the uses of the compositions in the treatment of human or animal tissue fibrosis, especially for human or animal renal interstitial fibrosis, glomerular sclerosis, liver fibrosis, pulmonary fibrosis, IPF, peritoneal fibrosis, myocardial fibrosis, dermatofibrosis, postsurgical adhesion, benign prostatic hyperplasia, skeletal muscle fibrosis, scleroderma, multiple sclerosis, pancreatic fibrosis, cirrhosis, myosarcoma, neurofibroma, pulmonary interstitial fibrosis, diabetic nephropathy, alzheimer disease or vascular fibrosis.

Abstract translation: 本发明涉及药物领域，本文提供的是新型含氮杂环化合物，其制备方法及其作为药物的用途，特别是用于治疗和预防组织纤维化。 本文还提供了包含含氮杂环化合物的药学上可接受的组合物和组合物在治疗人或动物组织纤维化中的用途，特别是用于人或动物肾间质纤维化，肾小球硬化，肝纤维化，肺纤维化，IPF，腹膜纤维化 ，心肌纤维化，皮肤纤维化，术后粘连，良性前列腺增生，骨骼肌纤维化，硬皮病，多发性硬化，胰腺纤维化，肝硬化，肌肉肉瘤，神经纤维瘤，肺间质纤维化，糖尿病肾病，阿尔茨海默病或血管纤维化。

公开(公告)号：US20190308939A1

公开(公告)日：2019-10-10

申请号：US16316055

申请日：2017-07-19

Applicant: SUNSHINE LAKE PHARMA CO., LTD.

Inventor： Runfeng LIN ,  Liang CHEN ,  Xiaojun WANG ,  Yingjun ZHANG ,  Jiancun ZHANG

IPC: C07D239/22 ,  C07C317/22 ,  C07C57/145

Abstract: Provided are salts of 2, 6-dimethylpyrimidone derivatives and uses thereof. Also provided are pharmaceutical compositions containing the salts.