公开(公告)号：US20190352311A1

公开(公告)日：2019-11-21

申请号：US16476290

申请日：2018-01-22

Applicant: SUNSHINE LAKE PHARMA CO., LTD. ,  NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED

Inventor： Wanjun TANG ,  Xinye YANG ,  Zheng GU ,  Chenlu LI ,  Zongyuan ZHANG ,  Zhifu WAN ,  Xiaojun WANG ,  Yingjun ZHANG

IPC: C07D495/04 ,  C07D519/00

Abstract: The present invention relates to a thienopyrimidine derivative and use thereof in medicine, and also to a pharmaceutical composition containing the compound. The compound or pharmaceutical composition is used for inhibiting acetyl-CoA carboxylase (ACC). The present invention also relates to a method of preparing such compound and pharmaceutical composition, as well as their use in the treatment or prevention of diseases regulated by acetyl-CoA carboxylase in mammals, especially in humans.

公开(公告)号：US20220267346A1

公开(公告)日：2022-08-25

申请号：US17624572

申请日：2019-07-02

Applicant: SUNSHINE LAKE PHARMA CO., LTD.

Inventor： Zheng GU ,  Wanjun TANG ,  Xinye YANG ,  Xuli WANG ,  Weihui YUAN ,  Yunzeng CUI ,  Wen YANG ,  Jianyu LIU ,  Yingjun ZHANG

IPC: C07D495/04

Abstract: Thienopyrimidine derivative having stereo configurations and use thereof in medicine. Also included are pharmaceutical compositions of the compounds. The compounds or pharmaceutical compositions may be used to inhibit acetyl-CoA carboxylase (ACC). A method for preparing the compounds and the pharmaceutical compositions, and use thereof in treatment or prevention of diseases associated with ACC regulation of mammals, in particular, humans.