公开(公告)号：US20150344464A1

公开(公告)日：2015-12-03

申请号：US14581746

申请日：2014-12-23

Applicant: SURFACE LOGIX, INC.

Inventor： ALESSANDRA BARTOLOZZI ,  STEWART CAMPBELL ,  HOPE FOUDOULAKIS ,  BRIAN KIRK ,  SIYA RAM ,  PAUL SWEETNAM

IPC: C07D413/14 ,  C07D403/14 ,  C07D405/14 ,  C07D403/12

CPC classification number: C07D413/14 ,  B82Y30/00 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14

Abstract: The present invention relates to inhibitors of ROCK1 and ROCK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and or ROCK2 that are useful for the treatment of disease.

Abstract translation: 本发明涉及ROCK1和ROCK2的抑制剂以及调节这些化合物的药代动力学和/或药效学性质的方法。 还提供抑制可用于治疗疾病的ROCK1和/或ROCK2的方法。

公开(公告)号：US20130131047A1

公开(公告)日：2013-05-23

申请号：US13715644

申请日：2012-12-14

Applicant: SURFACE LOGIX, INC.

Inventor： ALESSANDRA BARTOLOZZI ,  STEWART CAMPBELL ,  HOPE FOUDOULAKIS ,  BRIAN KIRK ,  SIYA RAM ,  PAUL SWEETNAM

IPC: C07D413/14 ,  C07D405/14 ,  C07D403/12 ,  C07D403/14 ,  C07D401/14

CPC classification number: C07D413/14 ,  B82Y30/00 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14

Abstract: The present invention relates to inhibitors of ROCK1 and ROCK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and or ROCK2 that are useful for the treatment of disease.