公开(公告)号：US20020063208A1

公开(公告)日：2002-05-30

申请号：US09994575

申请日：2001-11-27

Applicant: SURROMED, INC.

Inventor： Curtis Hastings

IPC: H01J049/00

CPC classification number: H01J49/0036 ,  G01N30/72 ,  G01N30/8624 ,  G01N30/8641 ,  H01J49/0431

Abstract: High-intensity, spiked noise is reduced in chromatography-mass spectrometry data by applying a nonlinear filter such as a moving median filter to the data. The filter is applied to individual mass chromatograms, plots of ion abundance versus retention time for each detected mass-to-charge ratio, and the filtered chromatograms are combined to form a filtered total ion current chromatogram. Standard linear filters are not effective for reducing noise in liquid chromatography-mass spectrometry (LC-MS) data because they assume a normal distribution of noise. LC-MS noise, however, is not normally distributed.

Abstract translation: 通过对数据应用诸如移动中值滤波器的非线性滤波器，在色谱 - 质谱数据中降低了高强度，加标噪声。 将过滤器应用于单个质量色谱图，每种检测质量 - 电荷比的离子丰度曲线与保留时间曲线，并将滤出的色谱图合并形成过滤的总离子电流色谱图。 标准线性滤波器对于降低液相色谱 - 质谱（LC-MS）数据中的噪声无效，因为它们假设噪声的正态分布。 然而，LC-MS噪声不是正态分布的。