公开(公告)号：US20240299928A1

公开(公告)日：2024-09-12

申请号：US18412909

申请日：2024-01-15

申请人： Elemental Scientific, inc.

发明人： Daniel R. Wiederin ,  Austin Schultz

IPC分类号： B01L3/00 ,  G01N1/38 ,  G01N21/71 ,  G01N21/73 ,  G01N35/10 ,  H01J49/04 ,  H01J49/10

CPC分类号： B01L3/502 ,  B01L3/523 ,  B01L3/567 ,  G01N1/38 ,  G01N21/73 ,  G01N35/1097 ,  H01J49/0431 ,  B01L2200/0605 ,  B01L2300/024 ,  B01L2300/049 ,  B01L2300/0806 ,  B01L2300/0861 ,  B01L2300/0867 ,  B01L2400/0487 ,  B01L2400/049 ,  B01L2400/06 ,  G01N2001/386 ,  G01N21/71 ,  G01N2035/1032 ,  H01J49/105

摘要： Sample preparation systems and methods are described having pump control, valve configurations, and control logic that facilitate automatic, inline preparation dilutions of a sample according to at least two dilution operating modes. A system embodiment includes, but is not limited to a first pump configured to drive a carrier fluid; a second pump configured to drive a diluent; and a plurality of selection valves fluidically coupled with the first pump and the second pump, the plurality of selection valves being configured to direct fluid flows from the first pump and the second pump according to at least two modes of operation to provide a single-stage sample dilution according to a first operating mode and to provide a dual-stage sample dilution according to a second operating mode.

公开(公告)号：US20240234117A9

公开(公告)日：2024-07-11

申请号：US18275342

申请日：2022-01-31

申请人： DH Technologies Development Pte. Ltd.

发明人： Thomas R. COVEY ,  Tim HAEBE ,  Chang LIU

IPC分类号： H01J49/04 ,  H01J49/24

CPC分类号： H01J49/0431 ,  H01J49/24

摘要： Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which an open port of a sampling probe for receiving a specimen may be exposed to washing solvent to wash the sampling probe while fluid within the sampling probe remains continuously flowing.

公开(公告)号：US20240136168A1

公开(公告)日：2024-04-25

申请号：US18275342

申请日：2022-01-31

申请人： DH Technologies Development Pte. Ltd.

发明人： Thomas R. COVEY ,  Tim HAEBE ,  Chang LIU

IPC分类号： H01J49/04 ,  H01J49/24

CPC分类号： H01J49/0431 ,  H01J49/24

摘要： Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which an open port of a sampling probe for receiving a specimen may be exposed to washing solvent to wash the sampling probe while fluid within the sampling probe remains continuously flowing.

公开(公告)号：US11959897B2

公开(公告)日：2024-04-16

申请号：US17828858

申请日：2022-05-31

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Jikang Wu ,  Hongxia Wang ,  Haibo Qiu ,  Ning Li

IPC分类号： G01N30/72 ,  G01N30/86 ,  H01J49/00 ,  H01J49/04 ,  H01J49/42 ,  G01N30/62

CPC分类号： G01N30/7233 ,  G01N30/8644 ,  H01J49/0031 ,  H01J49/0431 ,  H01J49/425 ,  G01N2030/628

摘要： Disclosed are methods for improving compound detection and characterization. Methods for characterizing a sample are disclosed. The methods can include providing a sample to a liquid chromatography system capable of sample separation to generate sample components; analyzing sample components by multiplexed targeted selected ion monitoring (SIM) to generate an inclusion list; and performing iterative mass spectral data-dependent acquisition (DDA) from the inclusion list, to identify individual sample components thereby characterizing the sample. In one example, multiplexed targeted SIMs and iterative MS2 DDA acquisition is used to increase robust compound identification for cell culture medium analysis.

公开(公告)号：US11942313B2

公开(公告)日：2024-03-26

申请号：US17601456

申请日：2019-05-08

申请人： SHIMADZU CORPORATION

发明人： Yusuke Tagawa ,  Yuki Ishikawa

IPC分类号： H01J49/00 ,  G01N27/623 ,  H01J49/04

CPC分类号： H01J49/0031 ,  G01N27/623 ,  H01J49/0009 ,  H01J49/0431 ,  H01J49/0036

摘要： A mass spectrometer according to an aspect of the present invention includes, to optimize N (where N is an integer of 2 or more) parameters that affect ionization efficiency in an ion source (31), a measurement controller (41) that causes respective units to repeatedly execute measurement on a sample containing a target component while changing values of the N parameters or a value set of M (where M is an integer smaller than N) parameters, in a plurality of stages, and a parameter determiner (53) that sequentially finds an optimum value for each parameter based on a result of the measurement executed under control of the measurement controller (41). At least one parameter whose physical quantity is temperature is optimized prior to all of the parameters whose physical quantities are other than temperature.

公开(公告)号：US20240096611A1

公开(公告)日：2024-03-21

申请号：US18262852

申请日：2022-02-08

申请人： DH Technologies Development Pte. Ltd.

发明人： Thomas R. COVEY ,  Chang LIU ,  Hui ZHANG

IPC分类号： H01J49/04

CPC分类号： H01J49/0431 ,  H01J49/0454

摘要： A method of sampling an ejection of a sample from a liquid container includes disposing the liquid container adjacent an open port in-terface. The container includes a sampling port. The open port interface en-gages with the sampling port. The sample from the liquid container is eject-ed, through the sampling port, and into the open port interface. The sample is analyzed with a mass spectrometry device.

公开(公告)号：US20240044853A1

公开(公告)日：2024-02-08

申请号：US18450837

申请日：2023-08-16

申请人： THERMO HYPERSIL-KEYSTONE LLC ,  DIONEX CORPORATION

发明人： Brandon Howard ROBSON ,  Xuefei SUN ,  Xiaodong LIU

IPC分类号： G01N30/72 ,  H01J49/04

CPC分类号： G01N30/7266 ,  H01J49/0431 ,  H01J49/167

摘要： An electrospray emitter assembly for interfacing a separation column to a mass spectrometer is disclosed. An emitter capillary includes an inlet end and an outlet end. A fitting is coupled to the inlet end of the emitter, configured to be removably connected to the separation column. A stop with a defined through hole is integrated proximate the inlet end of the emitter to produce a path for liquid to flow from the separation column to the emitter via the through hole where a voltage is applied to the liquid entering the emitter.

公开(公告)号：US20230349870A1

公开(公告)日：2023-11-02

申请号：US18111346

申请日：2023-02-17

申请人： UT-BATTELLE, LLC

发明人： Gary J. Van Berkel

IPC分类号： G01N30/72 ,  H01J49/04 ,  G01N1/00 ,  G01N35/10 ,  A61B5/00 ,  A61B10/02 ,  G01N1/20

CPC分类号： G01N30/7233 ,  H01J49/0431 ,  H01J49/0404 ,  G01N1/00 ,  G01N35/1095 ,  A61B5/443 ,  A61B10/02 ,  G01N1/20 ,  G01N2030/027

摘要： A system for sampling a sample material includes a probe which can have an outer probe housing with an open end. A liquid supply conduit within the housing has an outlet positioned to deliver liquid to the open end of the housing. The liquid supply conduit can be connectable to a liquid supply for delivering liquid at a first volumetric flow rate to the open end of the housing. A liquid exhaust conduit within the housing is provided for removing liquid from the open end of the housing. A liquid exhaust system can be provided for removing liquid from the liquid exhaust conduit at a second volumetric flow rate. A droplet dispenser can dispense drops of a sample or a sample-containing solvent into the open end of the housing. A sensor and a processor can be provided to monitor and maintain a liquid dome present at the open end.

公开(公告)号：US20190198309A1

公开(公告)日：2019-06-27

申请号：US16286574

申请日：2019-02-26

申请人： NINGBO UNIVERSITY ,  CHINA INNOVATION INSTRUMENT CO., LTD.

发明人： Luhong WEN ,  Peng ZHAO ,  Ruiqiang CHEN ,  Huanhuan HONG ,  Feng ZHOU

IPC分类号： H01J49/42 ,  G01N27/64 ,  H01J49/04 ,  G01N33/543 ,  H01J49/06

CPC分类号： H01J49/426 ,  G01N27/64 ,  G01N33/543 ,  H01J49/0031 ,  H01J49/0409 ,  H01J49/0431 ,  H01J49/062

摘要： A mass spectrometry system and a working method and an application thereof, and a sampling device. The mass spectrometry system includes an ion source, a sampling device and a mass spectrometer. The sampling device includes: a guide rail; a support adapted to move on the guide rail; a bearing member made from a hydrophobic material with two ends being fixed to the support; a plurality of containers for containing samples arranged on the support; a plurality of transport members made from a hydrophilic material and including a first portion provided on the bearing member and a second portion connected to the first portion and extending into each container; adjacent transport members being not in contact; and a drive module configured to drive the support to move on the guide rail such that a central axis of an exit port of the ion source passes through the first portion.

公开(公告)号：US20190122874A1

公开(公告)日：2019-04-25

申请号：US16167806

申请日：2018-10-23

申请人： Florida State University Research Foundation, Inc. ,  St. Louis University

发明人： Michael G. Roper ,  James L. Edwards

IPC分类号： H01J49/00 ,  H01J49/16 ,  H01J49/42 ,  G01N30/72

CPC分类号： H01J49/009 ,  G01N30/7233 ,  G01N30/7266 ,  G01N2030/623 ,  H01J49/0027 ,  H01J49/0036 ,  H01J49/0431 ,  H01J49/165 ,  H01J49/4225 ,  G01N30/32

摘要： Provided herein are methods for multiplexed sample analysis by mass spectrometry. The methods may be performed without the need for chemical tagging. The methods also may include the analogous use of frequency modulation to multiplex mass spectrometric analysis, which may be referred to as frequency-modulated continuous flow analysis electrospray ionization mass spectrometry (FM-CFA-ESI-MS).