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公开(公告)号：US12091414B2
公开(公告)日：2024-09-17
申请号：US17427357
申请日：2020-05-08
IPC分类号： C07D487/14
CPC分类号： C07D487/14 , C07B2200/13
摘要： The present application provides a upadacitinib salt compound and a preparation method therefor. The salt involved in the method in the present application has an easy preparation operation, a cheap raw material easy to get, and a good purification effect on upadacitinib, and is beneficial to industrial production.
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公开(公告)号：US11673862B2
公开(公告)日：2023-06-13
申请号：US16256596
申请日：2019-01-24
发明人： Peng Wang , Pixu Li , Qiang Wei , Yuanhua Liu
IPC分类号： C07D207/27 , A61K31/4015 , C07C53/19 , C07C53/50 , C07C67/307 , C07C69/63 , C07C71/00 , C07C209/08 , C07C231/14 , C07C233/05 , C07C237/06
CPC分类号： C07D207/27 , A61K31/4015 , C07C53/19 , C07C53/50 , C07C67/307 , C07C69/63 , C07C71/00 , C07C209/08 , C07C231/14 , C07C233/05 , C07C237/06
摘要： The present invention provides a scalable synthesis of enantiomerically pure brivaracetam, and related derivatives.
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公开(公告)号：US11926633B2
公开(公告)日：2024-03-12
申请号：US17272369
申请日：2019-08-26
IPC分类号： C07D487/14 , C07D207/08 , C07D207/16 , C07D241/20 , C07D487/04
CPC分类号： C07D487/14 , C07D207/08 , C07D207/16 , C07D241/20 , C07D487/04
摘要： The present disclosure relates to a JAK inhibitor upadacitinib intermediate and a preparation method therefor, and to a preparation method for a JAK inhibitor upadacitinib. The upadacitinib intermediate of the present application is as shown in Formula (II) or Formula (III),
wherein, R is a protective group of nitrogen atoms, and R1 is an open-chain or cyclic amine group. Compared with the prior art, the method for the synthesis of upadacitinib of the present application, significantly reduces cost, is environmentally-friendly. And the quality of the final product is well controlled.
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